HLCS and BACH1

Data Source: HiPPIP (Novel)

		HLCS	BACH1
Name		holocarboxylase synthetase	BTB domain and CNC homolog 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Heme Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Biotin	None
Diseases		Holocarboxylase synthetase deficiency	None
GWAS		Developmental language disorder ( 27016271 ) Developmental language disorder (linguistic errors) ( 27016271 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Intracranial aneurysm ( 29531279 ) Night sleep phenotypes ( 27126917 ) Red blood cell count ( 32888494 ) Seasonality and depression ( 30217971 )	Alanine aminotransferase levels ( 33547301 ) Aspartate aminotransferase levels ( 33547301 ) Creatine kinase levels ( 29403010 ) Haemorrhoidal disease ( 33888516 ) Pancreatic cancer ( 22158540 ) Selective IgA deficiency ( 27723758 ) Visceral fat ( 22589738 )
Novel Interactors		9 novel interactors: BACH1 IFNAR2 IFNGR2 IFT20 LANCL2 NGB SOD1 TGM3 WIPF1	1 novel interactors: HLCS
Interacting Genes		10 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15	18 interacting genes: ANAPC5 ATF2 BATF2 BRCC3 CFTR DDIT3 DYNLL1 HMMR KIF5A MAFB MAFK NR1D1 PATZ1 RBCK1 RPS27A TCF4 USP7 WAC
Entrez ID		3141	571
HPRD ID		08360	04127
Ensembl ID		ENSG00000159267	ENSG00000156273
Uniprot IDs		A0A8C8QSB1 P50747	O14867
PDB IDs		Not available	2IHC 8S7D 8UA3 8UA6 8UAH 8UBT 8UBU 8UBV 9GP5 9GR9 9GRA
GO Terms Enriched among Interactors		None	RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Integrated Stress Response Signaling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA-binding Transcription Factor Activity CAMP Response Element Binding Protein Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Leucine Zipper Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Response To Nutrient Levels DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA Damage Checkpoint Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Post-translational Protein Modification Nucleus Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Mononuclear Cell Differentiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Signal Transduction In Response To DNA Damage Macromolecule Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Leukocyte Differentiation Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Insulin Secretion Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Abducens Nucleus Development Hypoglossal Nucleus Development DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress