PAX6 and HOMER3

Number of citations of the paper that reports this interaction (PMID 16098226)
4

Data Source:
HPRD (two hybrid)

		PAX6	HOMER3
Gene Name		paired box 6	homer homolog 3 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Cellular_component Cytoplasm Cytosol Plasma Membrane Cell Junction Basal Part Of Cell Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding AT DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Co-SMAD Binding R-SMAD Binding HMG Box Domain Binding	Protein Binding Protein C-terminus Binding Protein Domain Specific Binding G-protein Coupled Glutamate Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Mitotic Spindle Orientation Blood Vessel Development Eye Development Cell Fate Determination Neural Crest Cell Migration Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Type B Pancreatic Cell Differentiation Pancreatic A Cell Development Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Axon Guidance Central Nervous System Development Salivary Gland Morphogenesis Visual Perception Response To Wounding Regulation Of Asymmetric Cell Division Organ Morphogenesis Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Regulation Of Neuron Projection Development Protein Ubiquitination Cerebellum Development Rhombomere Morphogenesis Olfactory Bulb Development Oligodendrocyte Cell Fate Specification Cerebral Cortex Regionalization Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Pituitary Gland Development Interkinetic Nuclear Migration Signal Transduction Involved In Regulation Of Gene Expression Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Lacrimal Gland Development Cellular Response To Insulin Stimulus Protein Localization To Organelle Cellular Response To Drug Eye Photoreceptor Cell Development Glucose Homeostasis Positive Regulation Of Cell Fate Specification Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Timing Of Cell Differentiation Embryonic Camera-type Eye Morphogenesis Neuron Fate Commitment Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Iris Morphogenesis Cornea Development In Camera-type Eye Positive Regulation Of Glucagon Secretion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Insulin Metabolic Process Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neuron Migration	Protein Targeting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry
Pathways		Peptide hormone metabolism Regulation of beta-cell development Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Body mass index ( 22344219)
Protein-Protein Interactions		30 interactors: CDX2 DIAPH1 DLG1 DYNLL1 EN1 EP300 HIPK2 HOMER3 HOXB1 INADL IPO13 LHX2 MAFG MITF NKIRAS2 PBX1 PKNOX1 PROX1 RAX RB1 RGS3 SHANK3 SIX3 SMARCA4 SOX10 SOX3 SUMO1 TBP TRIM11 VSX2	28 interactors: ABI2 ABI3 APP CEBPB DYNLL2 EAF1 EIF3D FAT1 FRYL GRM5 HOMER1 ITPR1 MOS NEBL PAX6 PKN1 POM121 PPP1R18 PSMA1 PSMA2 PSMC5 RUNX1T1 RYR1 SNRPF SRPK2 TRPC1 USP2 WIPF1
Entrez ID		5080	9454
HPRD ID		06167	07270
Ensembl ID		ENSG00000007372	ENSG00000051128
Uniprot IDs		F1T0F8 P26367 Q66SS1	B2RA10 Q9NSC5
PDB IDs		2CUE 6PAX	2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nervous System Development Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development RNA Metabolic Process System Development Eye Development Multicellular Organismal Development Regulation Of Transcription, DNA-templated Sensory Organ Development Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Morphogenesis Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Neurogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chordate Embryonic Development Cellular Nitrogen Compound Metabolic Process Generation Of Neurons Embryo Development Ending In Birth Or Egg Hatching Embryonic Morphogenesis Pattern Specification Process Tissue Development	Positive Regulation Of Cell Cycle Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Gene Expression Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Positive Regulation Of Ligase Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Intracellular Signal Transduction Response To Stimulus Signal Transduction Single-organism Behavior Cell Differentiation Regulation Of Ubiquitin-protein Transferase Activity Movement Of Cell Or Subcellular Component Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Arrest
Tagcloud ?		11p13 armes compaction conservation controversy cosmids editing evolution fried fugu genitourinary genomics gilley idea implying intergenic isoforms london mammals noncoding pufferfish quite raises rcn1 rubripes synteny usage usual wt1	abetapp alzheimer analyzing assembly coil coiled deposition derivative emphasis evh1 generation herein importantly interacting interaction interacts manipulate metabolism offer plaques players polymerization possibly seems senile serine tail
Tagcloud (Difference) ?		11p13 armes compaction conservation controversy cosmids editing evolution fried fugu genitourinary genomics gilley idea implying intergenic isoforms london mammals noncoding pufferfish quite raises rcn1 rubripes synteny usage usual wt1	abetapp alzheimer analyzing assembly coil coiled deposition derivative emphasis evh1 generation herein importantly interacting interaction interacts manipulate metabolism offer plaques players polymerization possibly seems senile serine tail
Tagcloud (Intersection) ?