HNRNPK and APBB1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		HNRNPK	APBB1
Description		heterogeneous nuclear ribonucleoprotein K	amyloid beta precursor protein binding family B member 1
Image
GO Annotations	Cellular Component	Chromatin Podosome Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Processing MRNA Processing Signal Transduction RNA Splicing Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Heterochromatin Formation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Random Inactivation Of X Chromosome Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Low-density Lipoprotein Particle Clearance	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglyceride levels ( 32203549)	Malaria ( 31844061)
Interacting Genes		226 interacting genes: - ABI1 ABI2 ADRB2 ANKRD28 APBB1 APOBEC1 APOBEC3C AQP5 AURKA BCL2L13 CALCOCO2 CBLB CCAR1 CCDC187 CCDC33 CDKN1A CEBPA CEBPB CIRBP CMTM5 CNNM3 CRBN CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 DSCR9 DUX4 EIF3F ELAVL1 ETNK2 FBXL18 FBXO4 FBXO7 FBXW7 FNDC3B FOXD4L1 FOXD4L3 FOXP1 FYN GFI1B GRAP2 GRB2 GZMA GZMK HBZ HCK HMGB1 HNRNPA0 HNRNPL HNRNPLL IRGC ITK ITSN1 ITSN2 KCTD8 KHDRBS1 KHDRBS2 KHDRBS3 KLF1 LINC03040 LYN MAP2K2 MAPK10 MARCHF8 MARK4 MATR3 MDM2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MISP MRPL9 MYPOP NCK2 NEDD4 NOTO NPDC1 OGT PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PEX39 PGAP6 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A QKI RALY RAMAC RASAL3 RASD1 RBFOX2 RBM10 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RNA18SN5 RNA28SN5 RNF26 RNF4 RPH3AL RTP5 SAFB SF1 SHANK3 SMAD3 SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TCF23 TERF2IP TH TLE5 TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 ZFC3H1 ZNF385C ZNF408 ZNF526 ZNF575 ZNF688 ZNF792 ZNRF2P1	72 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		3190	322
HPRD ID		02834	04087
Ensembl ID		ENSG00000165119	ENSG00000166313
Uniprot IDs		B4DUQ1 P61978	B7Z4M9 O00213
PDB IDs		1J5K 1KHM 1ZZI 1ZZJ 1ZZK 7CRE 7CRU 7RJK 7RJO	2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Extracellular Vesicle Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Angiogenesis Regulation Of RNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development MRNA Processing Negative Regulation Of Locomotion Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process
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