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FOXA3 and TLE2
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
FOXA3
TLE2
Gene Name
forkhead box A3
transducin-like enhancer of split 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Extracellular Space
Nucleus
Nucleoplasm
Molecular Function
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Factor Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Transcription Corepressor Activity
Protein Binding
Biological Process
Cellular Glucose Homeostasis
Transcription From RNA Polymerase II Promoter
Spermatogenesis
Cellular Response To Starvation
Chromatin Modification
Cell Differentiation
Endocrine Pancreas Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Regulation of beta-cell development
Regulation of gene expression in beta cells
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
ALX4
HMGB1
PPARA
TLE1
TLE2
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
Entrez ID
3171
7089
HPRD ID
03802
03025
Ensembl ID
ENSG00000170608
ENSG00000065717
Uniprot IDs
P55318
B4DE62
K7EMK7
Q04725
PDB IDs
1VTN
Enriched GO Terms of Interacting Partners
?
Organ Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Regulation Of DNA Binding
Regulation Of Transcription From RNA Polymerase II Promoter
System Development
Regulation Of Transcription, DNA-templated
Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Notch Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Anatomical Structure Development
Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Anatomical Structure Morphogenesis
Negative Regulation Of Wnt Signaling Pathway
Developmental Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of DNA-templated Transcription, Initiation
Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Base-excision Repair, DNA Ligation
Regulation Of Binding
Organ Development
Negative Regulation Of Receptor Biosynthetic Process
Epidermis Development
Wnt Signaling Pathway
Behavioral Response To Nicotine
Enamel Mineralization
RNA Metabolic Process
Negative Regulation Of Sequestering Of Triglyceride
Negative Regulation Of Cholesterol Storage
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Tagcloud
?
cancerous
cb
chinese
counterparts
csf1r
ctnnb1
drastic
functionally
genotyped
hbv
hcc
hot
jak1
livers
mafg
nras
oncogenes
onecut1
option
pik3ca
sixth
smo
spot
ssx1
suppressors
threat
transcriptomes
transcriptomic
valid
Tagcloud (Difference)
?
cancerous
cb
chinese
counterparts
csf1r
ctnnb1
drastic
functionally
genotyped
hbv
hcc
hot
jak1
livers
mafg
nras
oncogenes
onecut1
option
pik3ca
sixth
smo
spot
ssx1
suppressors
threat
transcriptomes
transcriptomic
valid
Tagcloud (Intersection)
?