RPRD1B and VAX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPRD1B	VAX1
Description		regulation of nuclear pre-mRNA domain containing 1B	ventral anterior homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Preinitiation Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Identical Protein Binding RNA Polymerase II C-terminal Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RNA Polymerase II Promoter Clearance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process MRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Glial Cell Differentiation Neuron Differentiation Skeletal Muscle Cell Differentiation Camera-type Eye Development Astrocyte Differentiation Roof Of Mouth Development Neuroepithelial Cell Differentiation
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS			Age at first birth ( 34211149) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 20023658)
Interacting Genes		22 interacting genes: BIN3 CDCA8 DDIT4L EIF4ENIF1 HMG20A HMGB3 HOXC4 NUTF2 PFDN6 PIP4K2B PSMB1 RASSF3 SPG21 STAT3 STEEP1 TERF2 TNPO2 TUBGCP4 UBE2I VAX1 VPS37C WEE2-AS1	14 interacting genes: DVL3 EAF1 ESRRG HECW1 HMBOX1 MLLT3 PICK1 POLR3C PSMB1 RCOR3 RPRD1B SDCBP2 SPANXN2 USP20
Entrez ID		58490	11023
HPRD ID		08513	16052
Ensembl ID		ENSG00000101413	ENSG00000148704
Uniprot IDs		Q9NQG5	Q5SQQ9
PDB IDs		4FLA 4FU3 4HFG 4NAD 4Q94 4Q96 9B9L
Enriched GO Terms of Interacting Partners?		Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Cellular Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Nucleus Protein Localization To Organelle Membrane Organization Negative Regulation Of Cell Differentiation Nuclear Import Signal Receptor Activity Establishment Of Localization In Cell Nuclear Export Negative Regulation Of Developmental Process Astrocyte Differentiation Intracellular Protein Localization Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair SUMO Conjugating Enzyme Activity Actin Cortical Patch Localization Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
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