HACD3 and NEAT1

Number of citations of the paper that reports this interaction (PubMedID 32140098)
39

Data Source:
BioGRID (unspecified method)

		HACD3	NEAT1
Description		3-hydroxyacyl-CoA dehydratase 3	nuclear paraspeckle assembly transcript 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Focal Adhesion Membrane Nuclear Membrane	RISC Complex Paraspeckles
	Molecular Function	GTPase Activator Activity Protein Binding Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Very-long-chain (3R)-3-hydroxyacyl-CoA Dehydratase Activity	MiRNA Binding Chromatin-protein Adaptor Activity Molecular Condensate Scaffold Activity MiRNA Inhibitor Activity Via Base-pairing RISC Complex Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Canonical NF-kappaB Signal Transduction JNK Cascade Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Rac Protein Signal Transduction Sphingolipid Biosynthetic Process Fatty Acid Elongation Very Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Intracellular Signal Transduction	LncRNA-mediated Post-transcriptional Gene Silencing Chromatin Organization Regulation Of MRNA Export From Nucleus Nuclear Body Organization MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Inflammatory Response Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of MiRNA Catabolic Process
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 34059833) Hemoglobin levels ( 32327693)	Acne (severe) ( 24927181) Glaucoma (primary open-angle) ( 29891935) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		3 interacting genes: HMGB2 NEAT1 RAC1	12 interacting genes: CTSD EGR1 GAR1 HACD3 MPC2 NEDD4L PINK1 RIMBP2 TRAF6 TUBB4A TUBB4B USP9X
Entrez ID		51495	283131
HPRD ID		11037
Ensembl ID		ENSG00000074696	ENSG00000245532
Uniprot IDs		H3BRL8 Q9P035
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Response To Molecule Of Bacterial Origin DNA Geometric Change Response To Lipopolysaccharide DNA Topological Change Positive Regulation Of Epithelial Cell Proliferation Non-sequence-specific DNA Binding, Bending Supercoiled DNA Binding Nucleus Organization Cell Motility Spermatid Nucleus Differentiation Chemotaxis Negative Regulation Of Gene Expression Kinocilium Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Interleukin-23 Production Regulation Of Interleukin-23 Production Regulation Of Ovarian Follicle Development Regulation Of ERK5 Cascade G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Rho GDP-dissociation Inhibitor Binding Auditory Receptor Cell Morphogenesis Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Neuron Maturation Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration Thioesterase Binding Erythrocyte Enucleation Cerebral Cortex GABAergic Interneuron Development Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Involved In Heart Morphogenesis Engulfment Of Apoptotic Cell Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Tangential Migration From The Subventricular Zone To The Olfactory Bulb Third Ventricle Development RISC Complex Binding Positive Regulation Of Synoviocyte Proliferation Paraspeckles Positive Regulation Of MiRNA Catabolic Process Regulation Of MRNA Export From Nucleus MiRNA Inhibitor Activity Via Base-pairing LncRNA-mediated Post-transcriptional Gene Silencing Locomotion Regulation Of Epithelial Cell Proliferation RAGE Receptor Binding Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Receptor Clustering Negative Regulation Of Fibroblast Migration Midbrain Dopaminergic Neuron Differentiation	Receptor Metabolic Process Protein Kinase B Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Recycling Regulation Of Protein Localization Interleukin-1-mediated Signaling Pathway Positive Regulation Of Post-translational Protein Modification Mitochondrial Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Organelle Organization Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Regulation Of Biological Quality Regulation Of Post-translational Protein Modification Cellular Response To Interleukin-8 Protein Ubiquitination K11-linked Deubiquitinase Activity Canonical NF-kappaB Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Insulin Catabolic Process Aspartic-type Peptidase Activity Autophagosome Organization Cysteine-type Endopeptidase Activity Antigen Processing And Presentation Autophagosome Assembly Insulin Receptor Recycling Positive Regulation Of Protein Metabolic Process Hemi-methylated DNA-binding Enzyme Binding Positive Regulation Of Protein Modification Process Cellular Response To Mycophenolic Acid Circadian Temperature Homeostasis Glomerular Mesangial Cell Proliferation Cellular Response To Heparin Regulation Of Progesterone Biosynthetic Process Response To Ischemia BMP Signaling Pathway Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Protein Stability Structural Constituent Of Cytoskeleton Internode Region Of Axon Intercellular Bridge Negative Regulation Of Sodium Ion Import Across Plasma Membrane
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