HLA-DOB and HLA-DMB

Number of citations of the paper that reports this interaction (PMID 9311912)
37

Data Source:
HPRD (in vivo)

		HLA-DOB	HLA-DMB
Gene Name		major histocompatibility complex, class II, DO beta	major histocompatibility complex, class II, DM beta
Image
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Membrane Integral Component Of Membrane MHC Class II Protein Complex	Lysosomal Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	MHC Class II Protein Complex Binding MHC Class II Receptor Activity	MHC Class II Protein Complex Binding
	Biological Process	Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		MHC class II antigen presentation Adaptive Immune System	MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) Kawasaki disease ( 22446962)
Protein-Protein Interactions		1 interactors: HLA-DMB	10 interactors: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 TEAD1
Entrez ID		3112	3109
HPRD ID		08368	00831
Ensembl ID		ENSG00000241106	ENSG00000242574
Uniprot IDs		P13765 Q5QNS2	P28068
PDB IDs		4I0P	1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Positive Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Protein Complex Assembly Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Cellular Macromolecular Complex Assembly Positive Regulation Of Immune Response Positive Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of Immune System Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Positive Thymic T Cell Selection Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Complex Assembly Thymic T Cell Selection Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Immune Response Regulation Of Immune System Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Selection Regulation Of Signal Transduction By P53 Class Mediator Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Immune Response 'de Novo' Posttranslational Protein Folding Positive Regulation Of Cell Cycle Phase Transition 'de Novo' Protein Folding Chaperone-mediated Protein Folding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cellular Component Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Lymphocyte Activation Macrophage Migration Inhibitory Factor Signaling Pathway Cellular Response To UV-C Cellular Response To Vitamin B1 Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Immune System Process Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Mitotic Cell Cycle Regulation Of T Cell Differentiation Regulation Of Response To DNA Damage Stimulus
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