HIF1A and HSP90AB1

Number of citations of the paper that reports this interaction (PMID 19802386)
16

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		HIF1A	HSP90AB1
Gene Name		hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	heat shock protein 90kDa alpha (cytosolic), class B member 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Motile Cilium RNA Polymerase II Transcription Factor Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol COP9 Signalosome Cell Surface Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding	UTP Binding CTP Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Sulfonylurea Receptor Binding Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding DATP Binding Ion Channel Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Transcription, DNA-templated Cellular Iron Ion Homeostasis Signal Transduction Notch Signaling Pathway Lactation Visual Learning Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Receptor Biosynthetic Process Response To Muscle Activity Axon Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process	Placenta Development Protein Folding Response To Unfolded Protein Axon Guidance Response To Salt Stress Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	HSF1 activation Axon guidance Semaphorin interactions Inflammasomes Attenuation phase Cellular response to heat stress HSF1-dependent transactivation Uptake and actions of bacterial toxins The NLRP3 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Sema3A PAK dependent Axon repulsion Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Uptake and function of diphtheria toxin Innate Immune System
Drugs			Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Adenosine-5\'-Diphosphate Radicicol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS
Protein-Protein Interactions		67 interactors: APEX1 AR ARNT ARNT2 ARNTL ATM CDC34 CDKN2A CITED2 COPS5 CREBBP CSNK2A1 CTNNB1 DAP3 EGLN1 EGLN2 EGLN3 EP300 FHL2 GNB2L1 HDAC1 HDAC2 HDAC5 HIF1AN HIF3A HSP90AA1 HSP90AB1 JUN MAFG MAFK MAPK1 MAPK3 MAX MCM7 MDM2 MTA1 NAA10 NAA11 NCOA1 NCOA2 NDN NR4A1 OS9 PER1 PGK1 PKM PLD1 PSMA7 RB1 RUNX2 RWDD3 SAT1 SEPT9 SP1 SSX4 STAT3 STUB1 SUMO1 SUMO2 TP53 TRAF6 TSGA10 UBE2D1 USP19 USP20 VHL VHLL	41 interactors: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 ESR1 FCHSD2 HIF1A IKBKB IKBKE IKBKG MAP3K14 MAP3K3 MAPK6 MKNK1 NR2C2 NR4A1 POT1 PPID SGTA SLC34A1 STARD13 STAT1 STAT3 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 USP50 WASL YWHAB
Entrez ID		3091	3326
HPRD ID		04517	06763
Ensembl ID		ENSG00000100644	ENSG00000096384
Uniprot IDs		A8MYV6 D0VY79 Q16665	B4DGL0 P08238 Q6PK50
PDB IDs		1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J	1QZ2 1UYM 3NMQ 3PRY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Response To Hypoxia Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Response To Growth Factor	Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of DNA Replication Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Telomere Maintenance Cellular Response To Stimulus Apoptotic Process Telomere Assembly Programmed Cell Death Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death Regulation Of Cell Death Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Signaling Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Homeostatic Process Regulation Of Organelle Organization Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Chromosome Organization Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Positive Regulation Of Gene Expression Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Difference) ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Intersection) ?