CFHR1 and LBP

Number of citations of the paper that reports this interaction (PubMedID 8663389)
0

Data Source:
HPRD (in vitro)

		CFHR1	LBP
Description		complement factor H related 1	lipopolysaccharide binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex Blood Microparticle	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome
	Molecular Function	Complement Component C3b Binding Protein Binding Identical Protein Binding	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipid Binding Coreceptor Activity Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	Complement Activation Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Lipid Transport Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways		Regulation of Complement cascade	Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration (MTAG) ( 32277175) Complement C3 and C4 levels ( 23028341) Complement factor H-related protein 1 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) IgA nephropathy ( 25305756) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)	Basophil percentage of white cells ( 32888494) Periodontitis (DPAL) ( 24024966)
Interacting Genes		4 interacting genes: APOA1 CFH LBP PRDX4	18 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		3078	3929
HPRD ID		00602	07175
Ensembl ID		ENSG00000244414	ENSG00000129988
Uniprot IDs		A0A8V8TNS5 A0A8V8TQ26 Q03591	P18428 Q8TCF0
PDB IDs		3ZD2 4MUC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heterotypic Cell-cell Adhesion Spherical High-density Lipoprotein Particle Apolipoprotein A-I Receptor Binding Peptidyl-methionine Modification Regulation Of Defense Response Lipid Binding Lipid Transport Locomotion Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cytokine Production Amyloid-beta Formation High-density Lipoprotein Particle Assembly Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Blood Microparticle Regulation Of Intestinal Lipid Absorption Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Extracellular Region Lipoprotein Particle Binding Extracellular Exosome High-density Lipoprotein Particle Binding High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Chemotaxis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Secretory Granule Lumen Regulation Of Cell Adhesion Molecule Production High-density Lipoprotein Particle Clearance Extracellular Space Serine-type Endopeptidase Complex Regulation Of Complement Activation, Alternative Pathway Complement Component C3b Binding Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Lipoteichoic Acid Binding Lipopolysaccharide Transport Cellular Response To Lipoteichoic Acid Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopeptide Binding Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity	Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Immune Response Immune System Process Positive Regulation Of Interleukin-1 Production Cytolysis By Host Of Symbiont Cells Positive Regulation Of Interleukin-1 Beta Production Extracellular Region Extracellular Exosome Regulation Of Immune System Process Humoral Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Adrenal Gland Development Blood Microparticle Identical Protein Binding Regulation Of Immune Response Killing By Host Of Symbiont Cells Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Response To Other Organism Response To Stress Activation Of Immune Response Lipopolysaccharide Binding Regulation Of Tumor Necrosis Factor Production Prostaglandin Production Involved In Inflammatory Response Biological Process Involved In Interaction With Symbiont Opsonin Receptor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Humoral Immune Response Positive Regulation Of Stress Fiber Assembly Regulation Of Chemotaxis Tertiary Granule Lumen Regulation Of Cytokine Production Regulation Of Defense Response Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell-substrate Adhesion Complement Activation Positive Regulation Of Cytokine Production Cellular Response To Butyrate Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Interleukin-8 Production Ferritin Complex Iron Ion Sequestering Activity Proteasome Complex
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