CFHR1 and PRDX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CFHR1	PRDX4
Description		complement factor H related 1	peroxiredoxin 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex Blood Microparticle	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Complement Component C3b Binding Protein Binding Identical Protein Binding	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Complement Activation Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Regulation of Complement cascade	Neutrophil degranulation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration (MTAG) ( 32277175) Complement C3 and C4 levels ( 23028341) Complement factor H-related protein 1 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) IgA nephropathy ( 25305756) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)
Interacting Genes		4 interacting genes: APOA1 CFH LBP PRDX4	27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		3078	10549
HPRD ID		00602	05935
Ensembl ID		ENSG00000244414	ENSG00000123131
Uniprot IDs		A0A8V8TNS5 A0A8V8TQ26 Q03591	Q13162 V9HW63
PDB IDs		3ZD2 4MUC	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heterotypic Cell-cell Adhesion Spherical High-density Lipoprotein Particle Apolipoprotein A-I Receptor Binding Peptidyl-methionine Modification Regulation Of Defense Response Lipid Binding Lipid Transport Locomotion Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cytokine Production Amyloid-beta Formation High-density Lipoprotein Particle Assembly Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Blood Microparticle Regulation Of Intestinal Lipid Absorption Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Extracellular Region Lipoprotein Particle Binding Extracellular Exosome High-density Lipoprotein Particle Binding High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Chemotaxis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Secretory Granule Lumen Regulation Of Cell Adhesion Molecule Production High-density Lipoprotein Particle Clearance Extracellular Space Serine-type Endopeptidase Complex Regulation Of Complement Activation, Alternative Pathway Complement Component C3b Binding Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Lipoteichoic Acid Binding Lipopolysaccharide Transport Cellular Response To Lipoteichoic Acid Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopeptide Binding Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity	Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin
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