CFHR1

Description		complement factor H related 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex Blood Microparticle
	Molecular Function	Complement Component C3b Binding Protein Binding Identical Protein Binding
	Biological Process	Complement Activation Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells
Pathways		Regulation of Complement cascade
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration (MTAG) ( 32277175) Complement C3 and C4 levels ( 23028341) Complement factor H-related protein 1 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) IgA nephropathy ( 25305756) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)
Interacting Genes		4 interacting genes: APOA1 CFH LBP PRDX4
Entrez ID		3078
HPRD ID		00602
Ensembl ID		ENSG00000244414
Uniprot IDs		A0A8V8TNS5 A0A8V8TQ26 Q03591
PDB IDs		3ZD2 4MUC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heterotypic Cell-cell Adhesion Spherical High-density Lipoprotein Particle Apolipoprotein A-I Receptor Binding Peptidyl-methionine Modification Regulation Of Defense Response Lipid Binding Lipid Transport Locomotion Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cytokine Production Amyloid-beta Formation High-density Lipoprotein Particle Assembly Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Blood Microparticle Regulation Of Intestinal Lipid Absorption Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import Extracellular Region Lipoprotein Particle Binding Extracellular Exosome High-density Lipoprotein Particle Binding High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Chemotaxis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Secretory Granule Lumen Regulation Of Cell Adhesion Molecule Production High-density Lipoprotein Particle Clearance Extracellular Space Serine-type Endopeptidase Complex Regulation Of Complement Activation, Alternative Pathway Complement Component C3b Binding Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Lipoteichoic Acid Binding Lipopolysaccharide Transport Cellular Response To Lipoteichoic Acid Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopeptide Binding Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity
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