HIST1H3H and NASP

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		HIST1H3H	NASP
Gene Name		histone cluster 1, H3h	nuclear autoantigenic sperm protein (histone-binding)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Histone Binding Hsp90 Protein Binding
	Biological Process	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing	Blastocyst Development DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Cell Cycle Cell Proliferation Protein Transport Histone Exchange
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: HTT NASP PHF1 TRIM24 ZDHHC17	14 interactors: H3F3B H3F3C HDAC6 HIST1H1A HIST1H1C HIST1H3G HIST1H3H HIST1H4A HIST2H3C LUC7L2 PTK2 TERF2 TERF2IP ULK2
Entrez ID		8357	4678
HPRD ID		11912	04423
Ensembl ID		ENSG00000203813	ENSG00000132780
Uniprot IDs		P68431	P49321 Q5T626
PDB IDs		1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51
Enriched GO Terms of Interacting Partners?		Neural Plate Formation Biosynthetic Process Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Response To Estrogen Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Histone H3-K27 Methylation Lactate Biosynthetic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Vitamin D Receptor Signaling Pathway Paraxial Mesoderm Formation Quinolinate Metabolic Process Cellular Response To CGMP Response To CGMP Serotonin Transport Sperm Ejaculation Neural Plate Morphogenesis L-glutamate Import DNA Replication-dependent Nucleosome Assembly Protein Transport Establishment Of Protein Localization Citrulline Metabolic Process Lactate Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone H3-K27 Methylation Macromolecule Biosynthetic Process Urea Cycle Neurotransmitter Uptake Cellular Response To Organic Cyclic Compound Urea Metabolic Process Regulation Of Histone H3-K27 Methylation Cellular Response To Lipid Thalamus Development Striatum Development Paraxial Mesoderm Morphogenesis Neural Plate Development Amino Acid Import Regulation Of Intracellular Signal Transduction Insemination Metal Ion Homeostasis Regulation Of Synaptic Transmission, Dopaminergic Response To Steroid Hormone Negative Regulation Of Histone Methylation Determination Of Adult Lifespan Grooming Behavior Lipoprotein Transport	DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly DNA Methylation Protein-DNA Complex Assembly Negative Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Macromolecular Complex Assembly Chromosome Organization DNA Modification Regulation Of Gene Expression, Epigenetic Chromatin Organization Gene Silencing DNA Conformation Change Cellular Component Assembly DNA Replication-dependent Nucleosome Assembly Organelle Organization Protein Complex Assembly DNA Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Methylation Blood Coagulation Hemostasis Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Regulation Of Body Fluid Levels Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Wound Healing Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Response To Wounding Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Negative Regulation Of Gene Expression RNA-dependent DNA Replication Regulation Of Gene Silencing Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening DNA Replication-independent Nucleosome Assembly Gene Expression
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Tagcloud (Difference) ?			1990s aerial barkley canada concentrated discharge discharges effort entrance fit fuca grid harbours inform inputs juan oily operations output pacific scenarios shore sound strait surveillance tourist trying vessel zeros
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