HCRT and NPFFR2

Number of citations of the paper that reports this interaction (PubMedID 12609745)
0

Data Source:
HPRD (in vivo)

		HCRT	NPFFR2
Description		hypocretin neuropeptide precursor	neuropeptide FF receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Postsynapse Neuronal Dense Core Vesicle Lumen	Plasma Membrane Actin Cytoskeleton Membrane
	Molecular Function	Neuropeptide Hormone Activity Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Opioid Receptor Binding
	Biological Process	Temperature Homeostasis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Response To Alcohol Positive Regulation Of Cold-induced Thermogenesis	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Pidolic acid
Diseases
GWAS
Interacting Genes		3 interacting genes: HCRTR1 HCRTR2 NPFFR2	6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1
Entrez ID		3060	10886
HPRD ID		03836	16244
Ensembl ID		ENSG00000161610	ENSG00000056291
Uniprot IDs		O43612	A0A804CC06 A0PJM9 Q9Y5X5
PDB IDs		1CQ0 1R02 1UVQ 1WSO 7L1U
Enriched GO Terms of Interacting Partners?		Orexin Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Receptor Activity Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity Peptide Hormone Binding Regulation Of Cytosolic Calcium Ion Concentration Response To Hormone Feeding Behavior G Protein-coupled Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Circadian Sleep/wake Cycle Process Regulation Of Circadian Sleep/wake Cycle, Wakefulness Opioid Receptor Binding Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Cellular Homeostasis Signaling Cell-cell Signaling Regulation Of Circadian Sleep/wake Cycle Circadian Behavior Rhythmic Behavior Cell Communication Regulation Of MAPK Cascade Chemical Homeostasis Synapse Regulation Of Behavior Signal Transduction Homeostatic Process Plasma Membrane Regulation Of Circadian Rhythm Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Detection Of Abiotic Stimulus Circadian Rhythm	Neuropeptide Hormone Activity Neuropeptide Signaling Pathway Regulation Of Response To Food Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Response To Nutrient Levels Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Regulation Of Neurotransmitter Secretion Feeding Behavior Type 2 Orexin Receptor Binding G Protein-coupled Receptor Binding Short-day Photoperiodism Regulation Of Postsynaptic Membrane Potential Regulation Of Secretion By Cell Regulation Of Nerve Growth Factor Production Neuropeptide Activity Somatostatin Secretion Cell-cell Signaling Cell Communication Regulation Of Secretion Signaling Neuropeptide Y Receptor Binding Perikaryon Vasopressin Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Perinuclear Region Of Cytoplasm Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Lumen Negative Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Positive Regulation Of Transmission Of Nerve Impulse Sleep Postsynapse Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Adult Feeding Behavior FK506 Binding Antifungal Humoral Response Intestinal Epithelial Cell Differentiation
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