HCRT and HCRTR1

Number of citations of the paper that reports this interaction (PMID 9491897)
470

Data Source:
HPRD (in vivo, in vitro)

		HCRT	HCRTR1
Gene Name		hypocretin (orexin) neuropeptide precursor	hypocretin (orexin) receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Cell Junction Secretory Granule Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of DNA Replication Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Excitatory Postsynaptic Membrane Potential	Neuropeptide Signaling Pathway Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: HCRTR1 HCRTR2 NPFFR2	4 interactors: ARRB1 ARRB2 CNR1 HCRT
Entrez ID		3060	3061
HPRD ID		03836	03863
Ensembl ID		ENSG00000161610	ENSG00000121764
Uniprot IDs		O43612	O43613
PDB IDs		1CQ0 1R02 1UVQ 1WSO
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide Cellular Response To Hormone Stimulus Synaptic Transmission Response To Organonitrogen Compound Regulation Of Circadian Rhythm Feeding Behavior Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Regulation Of Behavior Cellular Response To Organic Substance Circadian Sleep/wake Cycle Process Circadian Sleep/wake Cycle Response To Organic Substance Regulation Of CAMP-dependent Protein Kinase Activity Behavior Circadian Behavior Cell Surface Receptor Signaling Pathway Rhythmic Behavior Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Signal Transduction Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Signaling Cell Communication Circadian Rhythm Cellular Response To Stimulus Detection Of Abiotic Stimulus	G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Regulation Of Synaptic Transmission Regulation Of Receptor Internalization Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Receptor Internalization Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Behavior Negative Regulation Of Cellular Metabolic Process Receptor Metabolic Process Regulation Of Ion Transport Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Secretion Sensory Perception Of Pain Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Positive Regulation Of Transport Negative Regulation Of Catalytic Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Notch Signaling Pathway Regulation Of Protein Binding Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell Surface Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Cellular Localization Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Insulin Secretion Regulation Of Protein Ubiquitination G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Action Potential
Tagcloud ?		adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks
Tagcloud (Difference) ?		adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks
Tagcloud (Intersection) ?