HCRT and HCRTR2

Number of citations of the paper that reports this interaction (PMID 9491897)
470

Data Source:
HPRD (in vivo)

		HCRT	HCRTR2
Gene Name		hypocretin (orexin) neuropeptide precursor	hypocretin (orexin) receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Cell Junction Secretory Granule Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding	Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of DNA Replication Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Excitatory Postsynaptic Membrane Potential	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Feeding Behavior Circadian Sleep/wake Cycle Process Cellular Response To Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS			HIV-1 control ( 20041166)
Protein-Protein Interactions		3 interactors: HCRTR1 HCRTR2 NPFFR2	2 interactors: CD200 HCRT
Entrez ID		3060	3062
HPRD ID		03836	08374
Ensembl ID		ENSG00000161610	ENSG00000137252
Uniprot IDs		O43612	O43614 S4X0W3
PDB IDs		1CQ0 1R02 1UVQ 1WSO
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide Cellular Response To Hormone Stimulus Synaptic Transmission Response To Organonitrogen Compound Regulation Of Circadian Rhythm Feeding Behavior Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Regulation Of Behavior Cellular Response To Organic Substance Circadian Sleep/wake Cycle Process Circadian Sleep/wake Cycle Response To Organic Substance Regulation Of CAMP-dependent Protein Kinase Activity Behavior Circadian Behavior Cell Surface Receptor Signaling Pathway Rhythmic Behavior Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Signal Transduction Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Signaling Cell Communication Circadian Rhythm Cellular Response To Stimulus Detection Of Abiotic Stimulus	Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Neurological System Process Negative Regulation Of Potassium Ion Transport Eating Behavior Negative Regulation Of DNA Replication Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurological System Process Regulation Of Potassium Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Calcium Ion Transport Neuropeptide Signaling Pathway Negative Regulation Of Ion Transport Feeding Behavior Negative Regulation Of DNA Metabolic Process Membrane Depolarization Regulation Of DNA Replication Positive Regulation Of Cytosolic Calcium Ion Concentration
Tagcloud ?		adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks
Tagcloud (Difference) ?		adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks
Tagcloud (Intersection) ?