HCRT

Gene Name		hypocretin (orexin) neuropeptide precursor
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Gene Ontology Annotations	Cellular Component	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Cell Junction Secretory Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding
	Biological Process	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of DNA Replication Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: HCRTR1 HCRTR2 NPFFR2
Entrez ID		3060
HPRD ID		03836
Ensembl ID		ENSG00000161610
Uniprot IDs		O43612
PDB IDs		1CQ0 1R02 1UVQ 1WSO
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Peptide Cellular Response To Hormone Stimulus Synaptic Transmission Response To Organonitrogen Compound Regulation Of Circadian Rhythm Feeding Behavior Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Regulation Of Behavior Cellular Response To Organic Substance Circadian Sleep/wake Cycle Process Circadian Sleep/wake Cycle Response To Organic Substance Regulation Of CAMP-dependent Protein Kinase Activity Behavior Circadian Behavior Cell Surface Receptor Signaling Pathway Rhythmic Behavior Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Signal Transduction Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Signaling Cell Communication Circadian Rhythm Cellular Response To Stimulus Detection Of Abiotic Stimulus
Tagcloud ?		adenocarcinoma advanced chance chemoradiation chemoradiotherapy conducting forty hyperthermia hyperthermo inclusion interval ki locally longer neoadjuvant oncological pathological preoperative proven rectal regional relatively resectability seemed short staging surgery trends weeks