HCRT

Description		hypocretin neuropeptide precursor
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Postsynapse Neuronal Dense Core Vesicle Lumen
	Molecular Function	Neuropeptide Hormone Activity Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding
	Biological Process	Temperature Homeostasis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Response To Alcohol Positive Regulation Of Cold-induced Thermogenesis
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Pidolic acid
Diseases
GWAS
Interacting Genes		3 interacting genes: HCRTR1 HCRTR2 NPFFR2
Entrez ID		3060
HPRD ID		03836
Ensembl ID		ENSG00000161610
Uniprot IDs		O43612
PDB IDs		1CQ0 1R02 1UVQ 1WSO 7L1U
Enriched GO Terms of Interacting Partners?		Orexin Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Receptor Activity Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity Peptide Hormone Binding Regulation Of Cytosolic Calcium Ion Concentration Response To Hormone Feeding Behavior G Protein-coupled Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis Circadian Sleep/wake Cycle Process Regulation Of Circadian Sleep/wake Cycle, Wakefulness Opioid Receptor Binding Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Cellular Homeostasis Signaling Cell-cell Signaling Regulation Of Circadian Sleep/wake Cycle Circadian Behavior Rhythmic Behavior Cell Communication Regulation Of MAPK Cascade Chemical Homeostasis Synapse Regulation Of Behavior Signal Transduction Homeostatic Process Plasma Membrane Regulation Of Circadian Rhythm Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Detection Of Abiotic Stimulus Circadian Rhythm
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