HCCS and SNX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HCCS	SNX1
Description		holocytochrome c synthase	sorting nexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane	Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Cell Projection
	Molecular Function	Holocytochrome-c Synthase Activity Protein Binding Lyase Activity Heme Binding Metal Ion Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Animal Organ Morphogenesis Cytochrome C-heme Linkage Respiratory Electron Transport Chain	Intracellular Protein Transport Protein Transport Endosomal Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis
Pathways		Respiratory electron transport
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Cognitive performance ( 19734545)
Interacting Genes		3 interacting genes: CIDEB SENP2 SNX1	49 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ARMC12 ATXN7 CCDC148 CHRNG CMTM4 CMTM5 COQ3 EGFR F2R FAM25A FAM25C FAM25G FKBP7 FUNDC1 HCCS HGS INSR LEPR LIME1 MPC2 NRIP1 PDGFRB PLIN3 RABAC1 REEP5 REEP6 RHEX RTN3 RTN4 SASH1 SDCBP SDR16C5 SFT2D1 SH3GLB1 SNCA SNX2 SNX6 SYNGR1 SYP TK1 TMEM239 UFD1 VPS35
Entrez ID		3052	6642
HPRD ID		02085	03171
Ensembl ID		ENSG00000004961	ENSG00000028528
Uniprot IDs		P53701	Q13596
PDB IDs			2I4K 4FZS 8A1G 8ABQ 8AFZ
Enriched GO Terms of Interacting Partners?		Retromer, Tubulation Complex Transferrin Receptor Binding Lamellipodium Morphogenesis Leptin Receptor Binding COPI-coated Vesicle Lipid Transfer Activity Lipid Droplet Fusion Very-low-density Lipoprotein Particle Assembly SUMO-specific Endopeptidase Activity Protein Desumoylation Trophoblast Giant Cell Differentiation Labyrinthine Layer Development DeSUMOylase Activity Regulation Of DNA Endoreduplication Early Endosome To Golgi Transport Retromer Complex Insulin Receptor Binding Execution Phase Of Apoptosis Phosphatidic Acid Binding COPII Vesicle Coat Protein-lipid Complex Assembly COPII-coated Vesicle Cargo Loading Plasma Lipoprotein Particle Assembly Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Binding Lipid Storage Intermembrane Lipid Transfer Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Lipid Droplet Organization	Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Formation Cellular Response To Growth Factor Stimulus Receptor Complex Regulation Of Long-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Membrane Organization Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Cell Migration PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vesicle-mediated Transport Regulation Of Transport Retromer Complex Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Cell Motility Activin Receptor Activity Cell Migration Involved In Vasculogenesis Retromer, Tubulation Complex Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Lysosome Identical Protein Binding Membrane Organization Positive Regulation Of Transport Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasmic Vesicle Tubular Endosome Activin Receptor Complex Regulation Of Locomotion Establishment Of Protein Localization Synapse Early Endosome Membrane Cadherin Binding Regulation Of Synaptic Plasticity Positive Regulation Of MAPK Cascade Neuron Projection Activin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Transmembrane Receptor Protein Serine/threonine Kinase Activity
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