HCCS and SENP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HCCS	SENP2
Description		holocytochrome c synthase	SUMO specific peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body PML Body Nuclear Membrane
	Molecular Function	Holocytochrome-c Synthase Activity Protein Binding Lyase Activity Heme Binding Metal Ion Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Animal Organ Morphogenesis Cytochrome C-heme Linkage Respiratory Electron Transport Chain	Proteolysis Heart Development Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of DNA Endoreduplication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Regulation Of Macromolecule Metabolic Process Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Respiratory electron transport	SUMO is proteolytically processed
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Cognitive performance ( 19734545)	Diastolic blood pressure ( 27841878 28135244) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462 31152163) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 26969751 27841878)
Interacting Genes		3 interacting genes: CIDEB SENP2 SNX1	40 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP AR ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63
Entrez ID		3052	59343
HPRD ID		02085	07002
Ensembl ID		ENSG00000004961	ENSG00000163904
Uniprot IDs		P53701	Q9HC62
PDB IDs			1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?		Retromer, Tubulation Complex Transferrin Receptor Binding Lamellipodium Morphogenesis Leptin Receptor Binding COPI-coated Vesicle Lipid Transfer Activity Lipid Droplet Fusion Very-low-density Lipoprotein Particle Assembly SUMO-specific Endopeptidase Activity Protein Desumoylation Trophoblast Giant Cell Differentiation Labyrinthine Layer Development DeSUMOylase Activity Regulation Of DNA Endoreduplication Early Endosome To Golgi Transport Retromer Complex Insulin Receptor Binding Execution Phase Of Apoptosis Phosphatidic Acid Binding COPII Vesicle Coat Protein-lipid Complex Assembly COPII-coated Vesicle Cargo Loading Plasma Lipoprotein Particle Assembly Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Binding Lipid Storage Intermembrane Lipid Transfer Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Lipid Droplet Organization	Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Regulation Of Proteolysis Nuclear Membrane Protein Modification By Small Protein Conjugation Protein Localization To Nucleus PML Body Protein Tag Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Import Into Nucleus Nuclear Envelope Import Into Nucleus Very-low-density Lipoprotein Particle Chromatin Organization Post-translational Protein Modification Endoplasmic Reticulum Tubular Network Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Localization Sequence Binding High-density Lipoprotein Particle Regulation Of Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate-density Lipoprotein Particle Nucleus Organization Protein Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process PML Body Organization Chromatin Remodeling Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Regulation Of Protein Localization Molecular Condensate Scaffold Activity Programmed Cell Death Protein Modification Process NLS-dependent Protein Nuclear Import Complex Meiotic Nuclear Membrane Microtubule Tethering Complex
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