HBG2 and CYB5R3

Number of citations of the paper that reports this interaction (PMID 4403130)
13

Data Source:
HPRD (in vitro)

		HBG2	CYB5R3
Gene Name		hemoglobin, gamma G	cytochrome b5 reductase 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Hemoglobin Complex Blood Microparticle	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Hemoglobin Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	Oxygen Transporter Activity Iron Ion Binding Oxygen Binding Heme Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H AMP Binding ADP Binding Flavin Adenine Dinucleotide Binding NAD Binding FAD Binding
	Biological Process	Blood Coagulation Oxygen Transport	Cholesterol Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Blood Circulation L-ascorbic Acid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Factors involved in megakaryocyte development and platelet production	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			NADH Nicotinamide-Adenine-Dinucleotide Flavin-Adenine Dinucleotide
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929)
Protein-Protein Interactions		5 interactors: APP CYB5R3 HBB RPSA SMAD5	4 interactors: CYB5A CYCS HBG2 SPP1
Entrez ID		3048	1727
HPRD ID		00792	08942
Ensembl ID		ENSG00000196565	ENSG00000100243
Uniprot IDs		D9YZU9 P69892	P00387
PDB IDs		1FDH 4MQJ	1M91 1UMK
Enriched GO Terms of Interacting Partners?		Blood Circulation RNA 3'-end Processing Cholesterol Metabolic Process Sterol Metabolic Process RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Nitric Oxide Transport Platelet Activation Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Collateral Sprouting Axon Midline Choice Point Recognition RRNA Transport Mullerian Duct Regression Steroid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis RRNA 3'-end Processing Cell Adhesion Axon Choice Point Recognition Neuron Remodeling Osteoblast Fate Commitment Alcohol Metabolic Process Ribosomal Small Subunit Assembly Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Renal Absorption L-ascorbic Acid Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Response To Oxidative Stress Hemostasis Anatomical Structure Regression Maturation Of 5.8S RRNA Hydrogen Peroxide Catabolic Process Cellular Copper Ion Homeostasis Cellular Component Assembly Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cellular Response To BMP Stimulus Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Oxygen Transport RNA Processing Regulation Of Body Fluid Levels Wound Healing Ribosome Assembly Maturation Of SSU-rRNA Neuron Maturation MRNA Polyadenylation	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Mitochondrial Electron Transport, Cytochrome C To Oxygen Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Mitochondrial Electron Transport, Ubiquinol To Cytochrome C L-ascorbic Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Tagcloud ?		179a 377a african ala april arg augusta baby categorized difficulties e3 fetal ga gamma gamma125 gamma59 globin glu hbg1 hbvar lys newborn outside port royal silent usa variants
Tagcloud (Difference) ?		179a 377a african ala april arg augusta baby categorized difficulties e3 fetal ga gamma gamma125 gamma59 globin glu hbg1 hbvar lys newborn outside port royal silent usa variants
Tagcloud (Intersection) ?