HBG2 and RPSA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HBG2	RPSA
Gene Name		hemoglobin, gamma G	ribosomal protein SA
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Gene Ontology Annotations	Cellular Component	Cytosol Hemoglobin Complex Blood Microparticle	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytosolic Small Ribosomal Subunit 90S Preribosome Extracellular Vesicular Exosome
	Molecular Function	Oxygen Transporter Activity Iron Ion Binding Oxygen Binding Heme Binding	Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding Poly(A) RNA Binding
	Biological Process	Blood Coagulation Oxygen Transport	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Export From Nucleus Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Cell Adhesion Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Factors involved in megakaryocyte development and platelet production	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929)
Protein-Protein Interactions		5 interactors: APP CYB5R3 HBB RPSA SMAD5	27 interactors: ABCD1 ACADVL ACD ANKH C6orf106 CALM2 CBX5 CLEC4G CSF2RA DCTN6 GNMT HBG2 HNRNPD IL7R ITGA6 KARS LAMA2 NKX3-1 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3
Entrez ID		3048	3921
HPRD ID		00792	01038
Ensembl ID		ENSG00000196565	ENSG00000168028
Uniprot IDs		D9YZU9 P69892	P08865
PDB IDs		1FDH 4MQJ	3BCH 3J3A
Enriched GO Terms of Interacting Partners?		Blood Circulation RNA 3'-end Processing Cholesterol Metabolic Process Sterol Metabolic Process RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Nitric Oxide Transport Platelet Activation Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Collateral Sprouting Axon Midline Choice Point Recognition RRNA Transport Mullerian Duct Regression Steroid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis RRNA 3'-end Processing Cell Adhesion Axon Choice Point Recognition Neuron Remodeling Osteoblast Fate Commitment Alcohol Metabolic Process Ribosomal Small Subunit Assembly Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Renal Absorption L-ascorbic Acid Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Response To Oxidative Stress Hemostasis Anatomical Structure Regression Maturation Of 5.8S RRNA Hydrogen Peroxide Catabolic Process Cellular Copper Ion Homeostasis Cellular Component Assembly Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cellular Response To BMP Stimulus Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Oxygen Transport RNA Processing Regulation Of Body Fluid Levels Wound Healing Ribosome Assembly Maturation Of SSU-rRNA Neuron Maturation MRNA Polyadenylation	Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Fatty Acid Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of DNA Replication Wound Healing Negative Regulation Of Biosynthetic Process Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Cellular Response To Organic Substance Telomere Maintenance Via Telomere Lengthening Regulation Of Fatty Acid Biosynthetic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Protein ADP-ribosylation Lysyl-tRNA Aminoacylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Peroxisomal Long-chain Fatty Acid Import Fructose Transport Regulation Of DNA Biosynthetic Process Fatty Acid Beta-oxidation Regulation Of Chromosome Organization Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Glycogen Metabolic Process Response To Stress Regulation Of Protein ADP-ribosylation Inorganic Diphosphate Transport Positive Regulation Of Androgen Secretion Interleukin-7-mediated Signaling Pathway
Tagcloud ?		179a 377a african ala april arg augusta baby categorized difficulties e3 fetal ga gamma gamma125 gamma59 globin glu hbg1 hbvar lys newborn outside port royal silent usa variants	abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna
Tagcloud (Difference) ?		179a 377a african ala april arg augusta baby categorized difficulties e3 fetal ga gamma gamma125 gamma59 globin glu hbg1 hbvar lys newborn outside port royal silent usa variants	abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna
Tagcloud (Intersection) ?