HBG2 and HBM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HBG2	HBM
Description		hemoglobin subunit gamma 2	hemoglobin subunit mu
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Hemoglobin Complex Haptoglobin-hemoglobin Complex
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development	Oxygen Transport Erythrocyte Development
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Malate levels ( 31560688) Mean corpuscular hemoglobin concentration ( 28453575 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Body mass index ( 26426971) Glycated hemoglobin levels ( 31213470) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 31217584) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 28453575 27863252 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		11 interacting genes: APP CYB5R3 HBA1 HBA2 HBB HBM HBQ1 HBZ RPSA SMAD5 XPNPEP1	6 interacting genes: HBB HBD HBE1 HBG2 HBZ VIRMA
Entrez ID		3048	3042
HPRD ID		00792
Ensembl ID		ENSG00000196565	ENSG00000206177
Uniprot IDs		D9YZU9 P69892	Q6B0K9
PDB IDs		1FDH 4MQJ 4MQK 7QU4
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Myeloid Cell Development Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Haptoglobin Binding One-carbon Compound Transport Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Iron Ion Binding Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Metal Ion Binding Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Blood Microparticle Cellular Developmental Process Extracellular Exosome Response To Reactive Oxygen Species Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Defense Response Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Fas Signaling Pathway Response To Oxidative Stress PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport Hemoglobin Alpha Binding One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Blood Microparticle Cell Development Cellular Developmental Process Haptoglobin Binding Nitric Oxide Transport Hemoglobin Binding Metal Ion Binding RNA N6-methyladenosine Methyltransferase Complex Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Erythrocyte Maturation Peroxidase Activity Hydrogen Peroxide Metabolic Process Developmental Process
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