HARS1 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HARS1	TTC3
Description		histidyl-tRNA synthetase 1	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Cytosolic tRNA aminoacylation
Drugs		Histidine
Diseases
GWAS			Eye color traits ( 20463881)
Interacting Genes		10 interacting genes: EEF1B2 EEF1G MTNR1B OGT PSMC5 RPL5 TARS1 TNIK TTC3 WEE2-AS1	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		3035	7267
HPRD ID		00827	03773
Ensembl ID		ENSG00000170445	ENSG00000182670
Uniprot IDs		B4DDD8 B4E1C5 P12081	H7BZ57 P53804
PDB IDs		1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76 8YOR 8YP1
Enriched GO Terms of Interacting Partners?		Translation Protein Metabolic Process Translation Elongation Factor Activity Translational Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nuclear Proteasome Complex Regulation Of Proteolysis Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Eukaryotic Translation Elongation Factor 1 Complex Cytosol Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Proteasome-activating Activity Cytosolic Proteasome Complex Thyrotropin-releasing Hormone Receptor Binding Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Proteolysis Cytoplasmic Translation Positive Regulation Of Translation Negative Regulation Of Protein Neddylation Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Microvillus Assembly Pre-mRNA 5'-splice Site Binding Extracellular Exosome Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Carbon Catabolite Regulation Of Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process MRNA 5'-splice Site Recognition	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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