HARS1

Name	histidyl-tRNA synthetase 1
Structure
Interactors	10 interactors: EEF1B2 EEF1G MTNR1B OGT PSMC5 RPL5 TARS1 TNIK TTC3 WEE2-AS1
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation
Pathways	Cytosolic tRNA aminoacylation
Drugs	Histidine
GWAS	No GWAS studies recorded
Entrez ID	3035
HPRD ID	00827
Ensembl ID	ENSG00000170445
Uniprot IDs	B4DDD8 B4E1C5 P12081
PDB IDs	1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76 8YOR 8YP1
GO Terms Enriched among Interactors ?	Translation Protein Metabolic Process Translation Elongation Factor Activity Translational Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nuclear Proteasome Complex Regulation Of Proteolysis Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Eukaryotic Translation Elongation Factor 1 Complex Cytosol Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Proteasome-activating Activity Cytosolic Proteasome Complex Thyrotropin-releasing Hormone Receptor Binding Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Proteolysis Cytoplasmic Translation Positive Regulation Of Translation Negative Regulation Of Protein Neddylation Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Microvillus Assembly Pre-mRNA 5'-splice Site Binding Extracellular Exosome Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Carbon Catabolite Regulation Of Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process MRNA 5'-splice Site Recognition