HARS and RPL5

Number of citations of the paper that reports this interaction (PMID 8049265)
1

Data Source:
HPRD (in vivo, in vitro)

		HARS	RPL5
Gene Name		histidyl-tRNA synthetase	ribosomal protein L5
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Histidine-tRNA Ligase Activity ATP Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Poly(A) RNA Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Gene Expression	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs		L-Histidine
Diseases
GWAS			Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Protein-Protein Interactions		6 interactors: EEF1B2 EEF1G EIF3I RPL5 TARS TNIK	21 interactors: CSNK2A1 CSNK2B DCC EIF5A HARS IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D SPP1 SURF2 TNIP1 TNPO1 TSC22D1 UPF2 VHL
Entrez ID		3035	6125
HPRD ID		00827	04699
Ensembl ID		ENSG00000170445	ENSG00000122406
Uniprot IDs		B3KWE1 B4DDD8 B4E1C5 P12081	A2RUM7 B3KTM6 P46777
PDB IDs		1X59 2LW7 4G84 4G85	3J3B
Enriched GO Terms of Interacting Partners?		Translation Translational Elongation Cellular Protein Metabolic Process Protein Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Threonyl-tRNA Aminoacylation Translational Initiation Biosynthetic Process Activation Of JNKK Activity Ribonucleoprotein Complex Biogenesis Protein Localization To Membrane Microvillus Assembly Microvillus Organization	Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Cytoplasmic Transport Protein Localization To Organelle Establishment Of Protein Localization To Organelle Negative Regulation Of Collateral Sprouting Ribosomal Protein Import Into Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Intracellular Protein Transport Cellular Protein Localization Viral Process Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Programmed Cell Death Intracellular Transport Cell Death Death Protein Import Into Nucleus, Translocation Cellular Localization Response To External Stimulus Protein Localization Protein Transport Establishment Of Localization In Cell Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cellular Response To UV-C Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Vitamin B1 Negative Regulation Of Axonogenesis Chemotaxis MRNA Export From Nucleus Regulation Of MAPK Cascade Histidyl-tRNA Aminoacylation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury RNA Export From Nucleus Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Developmental Growth Spinal Cord Ventral Commissure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Growth Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?		ascertain botulinum cgi clinician compulsive dysphonia ghq hamilton hdrs impression obsessive pathologist psychometrics psychoticism ql rated rating reevaluated sds somatization somatoform spasmodic speech subscales toxin unilaterally vocal voice zung	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		ascertain botulinum cgi clinician compulsive dysphonia ghq hamilton hdrs impression obsessive pathologist psychometrics psychoticism ql rated rating reevaluated sds somatization somatoform spasmodic speech subscales toxin unilaterally vocal voice zung	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?