HADH and CLK1

Number of citations of the paper that reports this interaction (PubMedID 26167880)
0

Data Source:
BioGRID (enzymatic study)

		HADH	CLK1
Description		hydroxyacyl-CoA dehydrogenase	CDC like kinase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus
	Molecular Function	(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Identical Protein Binding NAD+ Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Spermatogenesis Response To Xenobiotic Stimulus Response To Hormone Response To Activity Cell Differentiation Response To Insulin Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis	Regulation Of RNA Splicing
Pathways		Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial protein degradation
Drugs		NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A Omega-3-carboxylic acids	Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		8 interacting genes: ADH1A APP CDC42 CLK1 FBXL17 FBXO7 SLC2A4 STAT1	170 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DDX23 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ENTREP2 ERFE FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MICU3 MKRN2 MTBP MTCL1 MTPAP MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIGP PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRP4K PRPF38A PRPF4 PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLC75A1 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF12 SRSF6 SRSF8 SSBP3 STIP1 STK31 SVOP TDRD9 TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148 ZNF830 ZRSR2
Entrez ID		3033	1195
HPRD ID		08372	09058
Ensembl ID		ENSG00000138796	ENSG00000013441
Uniprot IDs		A0A0D9SFP2 A0A140VK76 B3KTT6 Q16836	P49759
PDB IDs		1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS	1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3 7O9Y 7OA0 7OPG 8P04 8P08 8UWN
Enriched GO Terms of Interacting Partners?		Butanol Dehydrogenase (NAD+) Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Cellular Developmental Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Peptide Clathrin-coated Pit Protein-containing Complex Response To Cytokine Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Circulatory System Process Cellular Response To Type II Interferon Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona SCF Ubiquitin Ligase Complex Lewy Neurite Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Dendrite Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of Signaling Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Response To Cytokine Stimulus GBD Domain Binding	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process RNA Binding Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Catalytic Step 2 Spliceosome Nucleoplasm Nucleic Acid Binding MRNA Splice Site Recognition Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Negative Regulation Of RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RS Domain Binding Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Nuclear Matrix Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Topoisomerase Binding
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