HADH and ADH1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HADH	ADH1A
Description		hydroxyacyl-CoA dehydrogenase	alcohol dehydrogenase 1A (class I), alpha polypeptide
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Identical Protein Binding NAD+ Binding	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Butanol Dehydrogenase (NAD+) Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Spermatogenesis Response To Xenobiotic Stimulus Response To Hormone Response To Activity Cell Differentiation Response To Insulin Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis	Alcohol Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial protein degradation	Abacavir metabolism RA biosynthesis pathway Ethanol oxidation
Drugs		NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A Omega-3-carboxylic acids	NADH Fomepizole 4-Iodopyrazole N-Cyclopentyl-N-Cyclobutylformamide
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757)	Alcohol consumption (drinks per week) ( 30643258) Alcohol dependence ( 23456092 33290381) Regular attendance at a pub or social club ( 29970889) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: ADH1A APP CDC42 CLK1 FBXL17 FBXO7 SLC2A4 STAT1	2 interacting genes: CSNK2A2 HADH
Entrez ID		3033	124
HPRD ID		08372	00063
Ensembl ID		ENSG00000138796	ENSG00000187758
Uniprot IDs		A0A0D9SFP2 A0A140VK76 B3KTT6 Q16836	P07327
PDB IDs		1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS	1HSO 1U3T
Enriched GO Terms of Interacting Partners?		Butanol Dehydrogenase (NAD+) Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Cellular Developmental Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Peptide Clathrin-coated Pit Protein-containing Complex Response To Cytokine Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Circulatory System Process Cellular Response To Type II Interferon Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona SCF Ubiquitin Ligase Complex Lewy Neurite Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Dendrite Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of Signaling Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Response To Cytokine Stimulus GBD Domain Binding	Liver Development Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Wnt Signaling Pathway Protein Kinase CK2 Complex Gland Development Metanephric Part Of Ureteric Bud Development Calcium-induced Calcium Release Activity Migrasome Polycystin Complex Metanephric Smooth Muscle Tissue Development Metanephric Ascending Thin Limb Development Renal Artery Morphogenesis Distal Tubule Development Cellular Response To Hydrostatic Pressure Basal Cortex HLH Domain Binding Nephric Duct Development Mesonephric Duct Development Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Voltage-gated Monoatomic Cation Channel Activity Response To Water Voltage-gated Monoatomic Ion Channel Activity Male Gamete Generation Spermatogenesis Regulation Of Establishment Of Protein Localization Gamete Generation Muscle Alpha-actinin Binding Metanephric Epithelium Development Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cation Channel Complex Voltage-gated Sodium Channel Activity Renal Tubule Morphogenesis Protein Heterotetramerization Metanephric Tubule Development Outward Rectifier Potassium Channel Activity Actinin Binding Metanephric Nephron Tubule Development NAD+ Binding Centrosome Duplication Smooth Muscle Tissue Development Nephron Tubule Development
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