HABP2 and KNG1

Number of citations of the paper that reports this interaction (PMID 12452440)
4

Data Source:
HPRD (in vitro)

		HABP2	KNG1
Gene Name		hyaluronan binding protein 2	kininogen 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Glycosaminoglycan Binding	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	Proteolysis Cell Adhesion	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)
Protein-Protein Interactions		7 interactors: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 KNG1	28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN
Entrez ID		3026	3827
HPRD ID		04890	01970
Ensembl ID		ENSG00000148702
Uniprot IDs		Q14520	P01042
PDB IDs			2WOK 4ASQ 4ASR 4ECB 4ECC
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Glomerular Basement Membrane Development Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Renal System Development Neuromuscular Junction Development Urogenital System Development Glomerulus Development Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Angiogenesis Nephron Development Endothelial Cell Apoptotic Process Cell Differentiation Synapse Organization Retinal Blood Vessel Morphogenesis Regulation Of Angiogenesis Negative Regulation Of Endopeptidase Activity System Development Negative Regulation Of Peptidase Activity Kidney Development Blood Circulation Positive Regulation Of Renal Sodium Excretion Retina Vasculature Morphogenesis In Camera-type Eye Angiogenesis	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?			ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Difference) ?			ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington
Tagcloud (Intersection) ?