H1-0 and CCNE1

Number of citations of the paper that reports this interaction (PubMedID 17361108)
0

Data Source:
BioGRID (enzymatic study)

		H1-0	CCNE1
Description		H1.0 linker histone	cyclin E1
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GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosome Binding Nucleosomal DNA Binding	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Nucleosome Assembly Chromosome Condensation Heterochromatin Formation Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mesenchymal Stem Cell Proliferation
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS			Adult body size ( 32376654) Bladder cancer ( 20972438 24163127) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 27841878 28135244) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458) Walking pace ( 33128006)
Interacting Genes		20 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP2 PRKCB RAD51B XBP1	71 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A KPNB1 LATS2 LINC00664 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		3005	898
HPRD ID		00819	00455
Ensembl ID		ENSG00000189060	ENSG00000105173
Uniprot IDs		P07305	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		6HQ1 6LA2 6LA8 6LA9 6LAB 6N88 6N89 7COW 7DBP 7K5X 7XVL 7XX6 8TB9 9IPU	1W98 5L2W 7KJS 7XQK 8H4R 8H6P 8H6T 8VQ3 8VQ4
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Nucleus Cytosol Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Positive Regulation Of Establishment Of Protein Localization Nucleus Nuclear Import Signal Receptor Activity Regulation Of Mitotic Cell Cycle Phase Transition Nuclear Localization Sequence Binding G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition NLS-bearing Protein Import Into Nucleus Apoptotic Process Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Programmed Cell Death Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Cyclin Binding Ribosomal Protein Import Into Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nucleocytoplasmic Transport Intracellular Protein Localization Regulation Of Cell Cycle G2/M Phase Transition Protein Import Into Nucleus DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus Import Into Nucleus DNA Damage Response Histone Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport	Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleus Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin Binding Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Population Proliferation Cellular Response To Stress Cell Division Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of Chromosome Organization Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process G2/M Transition Of Mitotic Cell Cycle
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