H1F0 and PRKCB

Number of citations of the paper that reports this interaction (PMID 8034666)
35

Data Source:
BioGRID (enzymatic study)

		H1F0	PRKCB
Gene Name		H1 histone family, member 0	protein kinase C, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Golgi Apparatus Actin Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T6 Specific) Histone Binding Androgen Receptor Binding
	Biological Process	Apoptotic DNA Fragmentation Nucleosome Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Envelope Disassembly Signal Transduction Synaptic Transmission Blood Coagulation Negative Regulation Of Glucose Transport Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Histone H3-T6 Phosphorylation Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Carbohydrate Stimulus
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Signaling by the B Cell Receptor (BCR) Trafficking of GluR2-containing AMPA receptors Signaling by GPCR Mitotic Prophase Nuclear Envelope Breakdown Signaling by Wnt VEGFA-VEGFR2 Pathway M Phase Downstream signaling events of B Cell Receptor (BCR) VEGFR2 mediated cell proliferation Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Disinhibition of SNARE formation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Depolymerisation of the Nuclear Lamina Trafficking of AMPA receptors Cell Cycle, Mitotic beta-catenin independent WNT signaling GPCR downstream signaling Signaling by VEGF Activation of NF-kappaB in B cells WNT5A-dependent internalization of FZD4 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs			Vitamin E O-Phosphoethanolamine Ellagic Acid
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: APP CCNE1 CDK1 CDK2 CDK4 CDK5 GRB2 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PRKCB RAD51B XBP1	83 interactors: ADRBK1 AFAP1 ANXA2 ANXA7 BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2B GRIN2D GRM5 GSK3A GSK3B H1F0 HABP4 HIST1H1A HIST1H1B HIST1H3A HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LMNB1 LST1 MAPK6 MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PPP2R4 PTPN11 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8
Entrez ID		3005	5579
HPRD ID		00819	01499
Ensembl ID		ENSG00000189060	ENSG00000166501
Uniprot IDs		P07305	P05771
PDB IDs			2I0E
Enriched GO Terms of Interacting Partners?		Viral Process NLS-bearing Protein Import Into Nucleus Response To Stress Response To Wounding Blood Coagulation Cellular Response To Stimulus Hemostasis Regulation Of Protein Kinase Activity Response To Stimulus Signaling Regulation Of Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleocytoplasmic Transport Cell Communication Nuclear Transport Protein Import Into Nucleus Regulation Of Catalytic Activity Nuclear Import Regulation Of Phosphorylation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Response To Organic Substance Regulation Of Cell Cycle Regulation Of Body Fluid Levels Regulation Of Metabolic Process Wound Healing Apoptotic Process Signal Transduction Protein Import Regulation Of Phosphorus Metabolic Process Programmed Cell Death Histone Phosphorylation Positive Regulation Of Intracellular Protein Transport G1/S Transition Of Mitotic Cell Cycle Cell Death Death Protein Localization To Nucleus Regulation Of Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Process Cell Division Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Ribosomal Protein Import Into Nucleus	Regulation Of Cellular Component Organization Regulation Of Signaling Developmental Process Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Anatomical Structure Development Programmed Cell Death Multicellular Organismal Development Signaling Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Death Death Cell Communication Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Anatomical Structure Morphogenesis Response To Stimulus Response To External Stimulus Regulation Of Signal Transduction Response To Organic Substance Intracellular Signal Transduction Regulation Of Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Morphogenesis Response To Fibroblast Growth Factor System Development Innate Immune Response Response To Stress Fc Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Cellular Process Generation Of Neurons Regulation Of Kinase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		2achist1h3 4achist1h4 blots diacetyl die disrupts dividing elongating histh3 histh4 killed maa meiosis methoxyacetic overrepresented pachytene pe postexposure prophase spermatids spermatocyte spermatocytes spermatogenesis spermatogonia testes testis tetraacetyl unexposed zero	axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Difference) ?		2achist1h3 4achist1h4 blots diacetyl die disrupts dividing elongating histh3 histh4 killed maa meiosis methoxyacetic overrepresented pachytene pe postexposure prophase spermatids spermatocyte spermatocytes spermatogenesis spermatogonia testes testis tetraacetyl unexposed zero	axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Intersection) ?