PSMB11 and ATG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSMB11	ATG5
Description		proteasome subunit beta 11	autophagy related 5
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex	Cytoplasm Autophagosome Cytosol Axoneme Membrane Axon Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Synapse Phagophore Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Transferase Complex
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Atg8-family Ligase Activity
	Biological Process	Proteolysis T Cell Differentiation In Thymus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process CD8-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process	Autophagosome Assembly Mitophagy Blood Vessel Remodeling Immune System Process Regulation Of Cytokine Production Involved In Immune Response Chromatin Organization Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Fungus Response To Iron(II) Ion Positive Regulation Of Autophagy Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Negative Thymic T Cell Selection Innate Immune Response Negative Regulation Of Innate Immune Response Otolith Development Negative Regulation Of Defense Response To Virus Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Establishment Of Localization In Cell Ventricular Cardiac Muscle Cell Development Heart Contraction Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Axonal Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Autophagosome Maturation Regulation Of Cilium Assembly Response To Fluoride Negative Regulation Of Autophagic Cell Death Positive Regulation Of Viral Translation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Proteasome assembly Proteasome assembly	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Red cell distribution width ( 27863252 28957414 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 33875642 27363682) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 19838193 27399966 26502338 23273568) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 24387989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: ATG5 HGS PITX1 PROP1 TLX3	31 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 MYC NLRP6 OPTN PSMB11 RACK1 TECPR1 TEKT4 TIAM1 TRIM21 USP13 VCP WDFY3
Entrez ID		122706	9474
HPRD ID		19472	16051
Ensembl ID		ENSG00000222028	ENSG00000057663
Uniprot IDs		A5LHX3 B3KVC3	A0A2R8Y718 A9UGY9 Q7Z3H3 Q9H1Y0
PDB IDs			4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW 7W36
Enriched GO Terms of Interacting Partners?		Pituitary Gland Development Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Sequence-specific Double-stranded DNA Binding Somatotropin Secreting Cell Differentiation Central Nervous System Development Hypophysis Morphogenesis ESCRT-0 Complex Phagocytic Vesicle Lumen Macroautophagy Negative Regulation Of Autophagic Cell Death Otolith Development Phagophore Atg8-family Ligase Activity Response To Fluoride Positive Regulation Of Viral Translation Negative Stranded Viral RNA Replication Cellular Response To Nitrosative Stress Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression System Development Hypothalamus Cell Differentiation Positive Regulation Of Stress Granule Assembly Chaperone-mediated Autophagy Response To Iron(II) Ion Viral RNA Genome Replication Atg12-Atg5-Atg16 Complex Positive Regulation Of Mucus Secretion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Mucus Secretion Response To Nitrosative Stress Gland Development Adenohypophysis Development Autophagy Ventricular Cardiac Muscle Cell Development Cellular Response To Nitrogen Starvation Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Secretion Negative Thymic T Cell Selection Regulation Of Stress Granule Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process GABAergic Neuron Differentiation Cardiac Muscle Cell Apoptotic Process Negative T Cell Selection Transferase Complex	Autophagy Macroautophagy Regulation Of Autophagy Autophagosome Atg12-Atg5-Atg16 Complex Catabolic Process Autophagosome Membrane Regulation Of Autophagosome Maturation Autophagosome Assembly Cytosol Vacuole Organization Positive Regulation Of Catabolic Process Autophagosome Organization Cytoplasm Protein-containing Complex Disassembly Identical Protein Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Autophagosome Maturation C-terminal Protein Lipidation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Genome Replication Phagophore Assembly Site Membrane Macromolecule Catabolic Process Negative Stranded Viral RNA Replication Signaling Adaptor Activity Protein Transport Positive Regulation Of Autophagy Calpain Complex BAT3 Complex Binding Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Protein-containing Complex Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune System Process BH3 Domain Binding Regulation Of Proteolysis Establishment Of Protein Localization Response To Virus Stress Granule Disassembly Xenophagy Positive Regulation Of Autophagosome Maturation Viral RNA Genome Replication Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Xenophagy Post-translational Protein Modification Protein Catabolic Process Positive Regulation Of Cellular Component Organization Protein-containing Complex Organization
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