GUCA2B and DPCD

		GUCA2B	DPCD
Description		guanylate cyclase activator 2B	deleted in primary ciliary dyskinesia homolog (mouse)
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Extracellular Region Nucleus
	Molecular Function	Protein Binding Guanylate Cyclase Activator Activity	Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Body Fluid Secretion Response To Glucose CGMP-mediated Signaling Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Blood Pressure Adipose Tissue Development Renal Sodium Ion Absorption Energy Homeostasis	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Determination Of Left/right Symmetry Ventricular System Development Lateral Ventricle Development Third Ventricle Development Flagellated Sperm Motility Establishment Of Localization In Cell Left/right Pattern Formation
Pathways		Digestion
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549)	Mean corpuscular volume ( 32888494)
Interacting Genes		3 interacting genes: GUCY2D UBQLN1 UBQLN2	2 interacting genes: APP RUVBL2
Entrez ID		2981	25911
HPRD ID		03170	13247
Ensembl ID		ENSG00000044012	ENSG00000166171
Uniprot IDs		Q16661	Q5JQQ4 Q9BVM2
PDB IDs		1UYA 1UYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Peptide Receptor Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Lactose Synthase Activity Third Ventricle Development Positive Regulation Of Proteolysis Vacuole Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Galactosyltransferase Activity Guanylate Cyclase Activity Photoreceptor Outer Segment Membrane Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Cerebellar Purkinje Cell Layer Development Autophagy CGMP Biosynthetic Process Lateral Ventricle Development Left/right Pattern Formation Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Receptor Internalization Regulation Of Autophagy Regulation Of Clathrin-dependent Endocytosis CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Ventricular System Development Negative Regulation Of Transport Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process
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