GUCA2B

Description		guanylate cyclase activator 2B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome
	Molecular Function	Protein Binding Guanylate Cyclase Activator Activity
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Body Fluid Secretion Response To Glucose CGMP-mediated Signaling Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Blood Pressure Adipose Tissue Development Renal Sodium Ion Absorption Energy Homeostasis
Pathways		Digestion
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549)
Novel Interacting Genes		2 novel interacting genes: B4GALT2 DPCD
Interacting Genes		3 interacting genes: GUCY2D UBQLN1 UBQLN2
Entrez ID		2981
HPRD ID		03170
Ensembl ID		ENSG00000044012
Uniprot IDs		Q16661
PDB IDs		1UYA 1UYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Peptide Receptor Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Lactose Synthase Activity Third Ventricle Development Positive Regulation Of Proteolysis Vacuole Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Galactosyltransferase Activity Guanylate Cyclase Activity Photoreceptor Outer Segment Membrane Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Cerebellar Purkinje Cell Layer Development Autophagy CGMP Biosynthetic Process Lateral Ventricle Development Left/right Pattern Formation Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Receptor Internalization Regulation Of Autophagy Regulation Of Clathrin-dependent Endocytosis CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Ventricular System Development Negative Regulation Of Transport Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process
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