GUCA2B and B4GALT2

		GUCA2B	B4GALT2
Description		guanylate cyclase activator 2B	beta-1,4-galactosyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Golgi Membrane Nucleoplasm Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Guanylate Cyclase Activator Activity	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Protein Binding Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Body Fluid Secretion Response To Glucose CGMP-mediated Signaling Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Blood Pressure Adipose Tissue Development Renal Sodium Ion Absorption Energy Homeostasis	Carbohydrate Metabolic Process Protein Glycosylation Brain Development Memory Locomotory Behavior Visual Learning Cerebellar Purkinje Cell Layer Development Glycosylation
Pathways		Digestion	Keratan sulfate biosynthesis N-Glycan antennae elongation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576)
Interacting Genes		3 interacting genes: GUCY2D UBQLN1 UBQLN2	3 interacting genes: GPR35 MEOX2 PFDN6
Entrez ID		2981	8704
HPRD ID		03170	04928
Ensembl ID		ENSG00000044012	ENSG00000117411
Uniprot IDs		Q16661	O60909
PDB IDs		1UYA 1UYB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Peptide Receptor Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Lactose Synthase Activity Third Ventricle Development Positive Regulation Of Proteolysis Vacuole Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Galactosyltransferase Activity Guanylate Cyclase Activity Photoreceptor Outer Segment Membrane Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Cerebellar Purkinje Cell Layer Development Autophagy CGMP Biosynthetic Process Lateral Ventricle Development Left/right Pattern Formation Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Receptor Internalization Regulation Of Autophagy Regulation Of Clathrin-dependent Endocytosis CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Ventricular System Development Negative Regulation Of Transport Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process	Contractile Muscle Fiber
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