OSMR and GPRC5D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OSMR	GPRC5D
Description		oncostatin M receptor	G protein-coupled receptor class C group 5 member D
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex	Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Exosome
	Molecular Function	Cytokine Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding	G Protein-coupled Receptor Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Central retinal vein equivalent ( 31597446) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 26192919) Microalbuminuria ( 26631737) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Postoperative survival time in hepatocellular carcinoma ( 30945673 30945699) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908 26192919)
Interacting Genes		11 interacting genes: GAPDH GPRC5D IL6ST JAK1 JAK2 LHX2 MTDH OSM SGTB SLC10A6 UBQLN2	30 interacting genes: APOL3 BTN2A2 C14orf180 C1GALT1 CCL4 EMP1 ERMP1 FXYD3 FXYD6-FXYD2 GYPA IFITM3 IGFBP5 LHFPL5 LRRC25 MS4A6A OSMR PMP22 PRRT2 PVR SLC30A2 SLC66A1 SYNDIG1 TMEM120B TMEM19 TMEM208 TMEM79 TRARG1 TWSG1 UNC93B1 YIPF1
Entrez ID		9180	55507
HPRD ID		03446	07604
Ensembl ID		ENSG00000145623	ENSG00000111291
Uniprot IDs		Q99650	Q9NZD1
PDB IDs			8YZK 9IMA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Homotypic Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Binding Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of Acute Inflammatory Response Growth Hormone Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-17 Production Regulation Of Multicellular Organismal Process Regulation Of Platelet Aggregation T Cell Lineage Commitment Positive Regulation Of Cytokine Production Receptor Complex Response To Antibiotic Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Response To Cytokine Response To Peptide Regulation Of Acute Inflammatory Response Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Platelet Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Mesoderm Development Interleukin-35-mediated Signaling Pathway Oncostatin-M Receptor Binding Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Peptidyl-cysteine S-trans-nitrosylation	Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?