OSMR and IL6ST

Number of citations of the paper that reports this interaction (PMID 9188471)
9

Data Source:
HPRD (in vitro)

		OSMR	IL6ST
Gene Name		oncostatin M receptor	interleukin 6 signal transducer
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Oncostatin-M Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Oncostatin-M Receptor Activity Growth Factor Binding	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Interleukin-27 Receptor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Cell Proliferation Response To Cytokine Oncostatin-M-mediated Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways			Signaling by Interleukins Interleukin-6 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		5 interactors: GAPDH IL6ST JAK1 JAK2 OSM	31 interactors: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		9180	3572
HPRD ID		03446	02824
Ensembl ID		ENSG00000145623	ENSG00000134352
Uniprot IDs		Q99650	D6RH03 P40189 Q17RA0
PDB IDs			1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?		Cellular Response To Cytokine Stimulus Response To Cytokine Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Oncostatin-M-mediated Signaling Pathway Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Inflammatory Response Cytokine-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Cellular Response To Interferon-gamma Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance Response To Interferon-gamma Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Acute Inflammatory Response Peptidyl-amino Acid Modification Response To Organic Substance Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Immune Response Regulation Of Cellular Amino Acid Metabolic Process JAK-STAT Cascade Response To Antibiotic Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Cellular Ketone Metabolic Process Regulation Of Acute Inflammatory Response Regulation Of JAK-STAT Cascade Host Programmed Cell Death Induced By Symbiont Interleukin-11-mediated Signaling Pathway Peptidyl-cysteine S-trans-nitrosylation Histone H3-Y41 Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Interferon-gamma-mediated Signaling Pathway Immune System Process Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Interleukin-27-mediated Signaling Pathway Mineralocorticoid Receptor Signaling Pathway Positive Regulation Of Phosphorylation	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Organic Substance Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Cell Proliferation Cell Communication Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Regulation Of Cellular Ketone Metabolic Process Leukocyte Migration Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Regulation Of JAK-STAT Cascade
Tagcloud ?		apart auuua closed dependently dispensable ehlting erk1 fr180204 hepatocytes integrates intercellular involves knock mek1 mk2 osmrbeta p38mapk pentameric proximity sb203580 sensing socs socs3 stabilization transcript u0126 unexpectedly utr	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		apart auuua closed dependently dispensable ehlting erk1 fr180204 hepatocytes integrates intercellular involves knock mek1 mk2 osmrbeta p38mapk pentameric proximity sb203580 sensing socs socs3 stabilization transcript u0126 unexpectedly utr	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?