LRP12 and ACTN2

Number of citations of the paper that reports this interaction (PMID 12809483)
4

Data Source:
HPRD (in vivo, two hybrid)

		LRP12	ACTN2
Gene Name		low density lipoprotein receptor-related protein 12	actinin, alpha 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Coated Pit Integral Component Of Membrane	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Low-density Lipoprotein Receptor Activity Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Signal Transduction Regulation Of Growth	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport	Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 22570617) Vascular endothelial growth factor levels ( 21757650)
Protein-Protein Interactions		6 interactors: ACTN2 GNB2L1 MYOT NMRK2 SNAPIN ZFYVE9	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		29967	88
HPRD ID		17447	00019
Ensembl ID		ENSG00000147650	ENSG00000077522
Uniprot IDs		Q59H02 Q9Y561	B2RCS5 P35609 Q59FD9
PDB IDs			1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of CAMP Catabolic Process Terminal Button Organization Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Autophagic Vacuole Maturation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Muscle Contraction Microspike Assembly Regulation Of Cellular Localization Negative Regulation Of Oxidative Stress-induced Neuron Death Muscle System Process Negative Regulation Of Protein Localization To Cell Surface SMAD Protein Import Into Nucleus Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Mitochondrial Depolarization Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Regulation Of Hydrogen Peroxide-induced Cell Death SMAD Protein Complex Assembly Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Phagocytosis Synaptic Vesicle Maturation Negative Regulation Of Potassium Ion Transmembrane Transport Vesicle-mediated Transport Negative Regulation Of Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Mitochondrial Depolarization Positive Regulation Of Protein Oligomerization Regulation Of Protein Localization To Cell Surface Anterograde Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Negative Regulation Of Potassium Ion Transport Negative Regulation Of Myoblast Differentiation Secretion By Cell Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Protein Oligomerization Regulation Of Potassium Ion Transmembrane Transporter Activity Anterograde Axon Cargo Transport NAD Biosynthetic Process Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Potassium Ion Transport Viral Process Endosome To Lysosome Transport Positive Regulation Of Embryonic Development Actin-myosin Filament Sliding	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?