LRP12 and NMRK2

Number of citations of the paper that reports this interaction (PubMedID 12809483)
0

Data Source:
HPRD (two hybrid, in vivo)

		LRP12	NMRK2
Description		LDL receptor related protein 12	nicotinamide riboside kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Clathrin-coated Pit Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Integrin Binding Protein Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Nicotinate Riboside Kinase Activity Metal Ion Binding Ribosylnicotinamide Kinase Activity Ribosylnicotinate Kinase Activity
	Biological Process	Neuron Migration Endocytosis Cell Adhesion Signal Transduction Cell Migration Neuron Projection Development Integrin Activation Regulation Of Growth Lymphocyte Migration Into Lymphoid Organs	NADP+ Biosynthetic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process NAD+ Biosynthetic Process Via The Salvage Pathway Negative Regulation Of Myoblast Differentiation
Pathways		Retinoid metabolism and transport	Nicotinate metabolism
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Daytime nap ( 33568662) Glaucoma (primary open-angle) ( 22570617) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Irritable mood ( 29500382) Periodontitis (DPAL) ( 24024966) Systolic blood pressure ( 28739976) Vascular endothelial growth factor levels ( 21757650)	Leukocyte telomere length ( 32109421)
Interacting Genes		7 interacting genes: ACTN2 MYOT NMRK2 RACK1 SNAPIN SNCA ZFYVE9	6 interacting genes: APP CDKN1A IGF2 ITGB1 LRP12 SAT1
Entrez ID		29967	27231
HPRD ID		17447	16371
Ensembl ID		ENSG00000147650	ENSG00000077009
Uniprot IDs		Q59H02 Q9Y561	Q9NPI5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Structural Constituent Of Muscle Positive Regulation Of Transport Actin Cytoskeleton Actin Filament Uncapping Regulation Of Vesicle-mediated Transport Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Synaptic Vesicle Transport SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neuronal Cell Body Positive Regulation Of Late Endosome To Lysosome Transport Actin Binding Positive Regulation Of Protein Localization To Cell Periphery Enzyme Activator Activity Titin Z Domain Binding Cytoplasm Negative Regulation Of Transport Regulation Of Membrane Potential Neurotransmitter Transport Regulation Of Neurotransmitter Secretion Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Nicotinate Riboside Kinase Activity Cell Junction Organization Regulated Exocytosis Establishment Of Vesicle Localization Regulation Of Cellular Localization Positive Regulation Of Cation Transmembrane Transport Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Ribosylnicotinate Kinase Activity Ribosylnicotinamide Kinase Activity Cell Projection Positive Regulation Of Intracellular Transport Microspike Assembly Z Disc	Integrin Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Cell Population Proliferation Regulation Of Growth Insulin Receptor Binding Molecular Function Activator Activity Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Immune System Process Amyloid-beta Complex Developmental Growth Growth Cone Lamellipodium Synaptic Membrane Response To Light Stimulus Positive Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Clathrin-coated Pit Positive Regulation Of Multicellular Organismal Process Protein Heterodimerization Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Population Proliferation Striated Muscle Cell Differentiation Myoblast Fate Specification Integrin Alpha7-beta1 Complex Spermidine Binding Regulation Of Cell Cycle Acetylcholine Receptor Activator Activity Response To Interleukin-1 Associative Learning Neuron Projection Development Positive Regulation Of Intracellular Signal Transduction Endocytosis Lipoprotein Particle Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Import Response To Radiation Protein Kinase Binding
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