RCOR3 and LCA5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RCOR3	LCA5
Description		REST corepressor 3	lebercilin LCA5
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Nucleoplasm Nucleolus Cytoplasm Mitochondrion Centrosome Cytoskeleton Cilium Axoneme Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection
	Molecular Function	Transcription Corepressor Activity Protein Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Protein Transport Intraciliary Transport Photoreceptor Cell Maintenance
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR)
GWAS		Plateletcrit ( 32888494)	Glucose homeostasis traits ( 25524916) Hoarding ( 21302353) Presence of antiphospholipid antibodies ( 23509613)
Interacting Genes		73 interacting genes: ABI1 ANKRD11 APP BORCS6 CBY2 CCDC102B CCDC106 CCHCR1 CDR2 CEP55 CEP63 CEP70 EFHC2 FAM81A FSD2 GKAP1 GLRX3 GOLGA2 GPRASP3 GRIPAP1 GSE1 HAUS3 HMBOX1 HOOK2 HSF2BP ICA1L IKZF3 ING5 ISY1-RAB43 KDM1A KRT15 KRT18 KRT19 KRT24 KRT27 KRT31 KRT40 KRT75 LCA5 LHX3 LUZP4 LZTS2 MAGEA6 MCC MESD MID2 MIPOL1 MTUS2 NDUFB7 NECAB2 NINL NRDE2 NUTM1 PHF19 PIH1D1 PRDM14 PTTG2 STN1 SUMO2 TFIP11 TRAF1 TRAF2 TRIM27 TRIM42 TRIM54 TSGA10 TULP3 TXLNA USHBP1 VAX1 YWHAQ ZNF383 ZNF688	6 interacting genes: GCC1 RCOR3 SRPK2 SUFU TFIP11 TXLNA
Entrez ID		55758	167691
HPRD ID		08338	10791
Ensembl ID		ENSG00000117625	ENSG00000135338
Uniprot IDs		Q9P2K3	A0A384MDJ7 Q86VQ0
PDB IDs		4CZZ
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Protein Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule TORC1 Complex Assembly Cytoskeleton Organization Epithelial Cell Differentiation Microtubule-based Process Telomeric DNA Binding Centrosome	Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Cellular Response To Drug Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Positive Regulation Of Cellular Response To Drug Positive Regulation Of Response To Drug Nuclear Speck Organization GLI-SUFU Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere Transcription Corepressor Activity Regulation Of Response To Drug Spinal Cord Dorsal/ventral Patterning Golgi Trans Cisterna R-loop Processing
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