SP100 and RBM39

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SP100	RBM39
Description		SP100 nuclear antigen	RNA binding motif protein 39
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body PML Body Mre11 Complex Nuclear Periphery	Nucleus Nucleoplasm Microtubule Cytoskeleton Nuclear Speck Protein-containing Complex Centriolar Satellite
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Protein Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromo Shadow Domain Binding	Nucleic Acid Binding RNA Binding Protein Binding RS Domain Binding U1 SnRNP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Negative Regulation Of Endothelial Cell Migration DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Type II Interferon Maintenance Of Protein Location Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Regulation Of Viral Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway	RNA Processing MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome
Pathways		SUMOylation of DNA damage response and repair proteins Interferon gamma signaling	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREBBP CREM DNMT3A DYRK2 ETS1 GIPC2 HEMGN HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML POLR3C RANBP2 RBM39 RTP5 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBE2I USPL1 ZC2HC1A	56 interacting genes: AK8 APP ARL6IP4 ASH2L BANP CEBPA CHERP CLK2 CSNK2A1 DARS1-AS1 DCAF15 DDX39B DVL3 ESR1 ESR2 FAM200A GOLGA2 HOMEZ INO80B JUN KHDC4 KMT2A KRTAP12-2 MCPH1 MLX MTNR1A NCOA6 NKAP NKAPD1 OGT PGR PHC2 POU6F2 PRPF38A PRPF40A RBBP5 RBM23 RBM25 REL RNF113A RP9P SAP30BP SDCBP SF3B4 SP100 SREK1 SREK1IP1 SRRM4 THAP1 TOE1 TTC14 U2AF2 USP7 WDR5 ZBTB22 ZCCHC10
Entrez ID		6672	9584
HPRD ID		06844	09201
Ensembl ID		ENSG00000067066	ENSG00000131051
Uniprot IDs		P23497	A0A384NQ03 B4DRA0 Q14498
PDB IDs		1H5P 4PTB 5FB0 5FB1 5PWE 5PWF 5PWG 5PWH 5PWI 5PWJ 5PWK 5PWL 5PWM 5PWN 5PWO 5PWP 5PWQ 5PWR 5PWS 5PWT 5PWU 5PWV 5PWW 5PWX 5PWY 5PWZ 5PX0 5PX1 5PX2 5PX3 5PX4 5PX5 5PX6 5PX7 5PX8 5PX9 5PXA 5PXB 5PXC 5PXD 5PXE 5PXF 5PXG 5PXH 5PXI 5PXJ 5PXK 5PXL 5PXM 5PXN 5PXO 5PXP 5PXQ 5PXR 5PXS 5PXT 5PXU 5PXV 5PXW 5PXX 5PXY 5PXZ 5PY0 5PY1 5PY2 5PY3 5PY4 5PY5 5PY6 5PY7 5PY8 5PY9 5PYA 5PYB 5PYC 5PYD 5PYE 5PYF 5PYG 5PYH 5PYI 5PYJ 5PYK 5PYL 5PYM 5PYN 5PYO 5PYP 5PYQ 5PYR 5PYS 5PYT 5PYU 5PYV 5PYW 5PYX 5PYY 5PYZ 5PZ0 5PZ1 5PZ2 5PZ3 5PZ4 5PZ5 5PZ6 5PZ7 5PZ8 5PZ9 5PZA 5PZB 5PZC 5PZD 5PZE 5PZF 5PZG 5PZH 5PZI 5PZJ 6G5N 6G5P	2JRS 2MHN 4OO6 4OZ0 4OZ1 4YUD 6PAI 6Q0R 6Q0V 6Q0W 6SJ7 6UD7 6UE5 7Q33
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Nucleoplasm PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Body Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process PML Body Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Nucleus Nuclear Body SUMO Transferase Activity Chromosome, Telomeric Region Shelterin Complex Presynaptic Cytosol Postsynaptic Cytosol DNA Damage Response Nuclear Telomere Cap Complex Chromatin Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Nucleus Organization Telomere Capping Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Heterochromatin Negative Regulation Of Transcription By RNA Polymerase II Post-translational Protein Modification Chromatin Remodeling Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process	Nucleoplasm RNA Splicing MRNA Processing MRNA Metabolic Process MLL1/2 Complex Regulation Of RNA Metabolic Process Histone Methyltransferase Complex Nucleus RNA Metabolic Process MLL3/4 Complex RNA Processing Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression, Epigenetic Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Spliceosomal Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Estrogen Response Element Binding Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Set1C/COMPASS Complex Negative Regulation Of Biosynthetic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Regulation Of Gluconeogenesis Negative Regulation Of RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nuclear Steroid Receptor Activity MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Estrogen Receptor Activity RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process RNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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