SP100 and NIPBL

Number of citations of the paper that reports this interaction (PubMedID 15882967)
0

Data Source:
BioGRID (pull down)

		SP100	NIPBL
Description		SP100 nuclear antigen	NIPBL cohesin loading factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body PML Body Mre11 Complex Nuclear Periphery	Chromatin Nucleus Nucleoplasm Chromosome Cytosol Integrator Complex SMC Loading Complex Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Protein Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromo Shadow Domain Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Mediator Complex Binding Histone Deacetylase Binding Cohesin Loader Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Negative Regulation Of Endothelial Cell Migration DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Type II Interferon Maintenance Of Protein Location Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Regulation Of Viral Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway	Mitotic Sister Chromatid Segregation Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Mitotic Sister Chromatid Cohesion Brain Development Heart Development Sensory Perception Of Sound Intracellular Protein Localization Regulation Of Gene Expression Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gallbladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration
Pathways		SUMOylation of DNA damage response and repair proteins Interferon gamma signaling	Cohesin Loading onto Chromatin
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Height ( 25282103 28552196 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		39 interacting genes: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREBBP CREM DNMT3A DYRK2 ETS1 GIPC2 HEMGN HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML POLR3C RANBP2 RBM39 RTP5 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBE2I USPL1 ZC2HC1A	11 interacting genes: CBX5 CDK6 DBN1 DSCR9 HINFP MAP1LC3C PCNA PCNT PRSS23 SP100 SUMO2
Entrez ID		6672	25836
HPRD ID		06844	10560
Ensembl ID		ENSG00000067066	ENSG00000164190
Uniprot IDs		P23497	A0A590UJS4 Q6KC79
PDB IDs		1H5P 4PTB 5FB0 5FB1 5PWE 5PWF 5PWG 5PWH 5PWI 5PWJ 5PWK 5PWL 5PWM 5PWN 5PWO 5PWP 5PWQ 5PWR 5PWS 5PWT 5PWU 5PWV 5PWW 5PWX 5PWY 5PWZ 5PX0 5PX1 5PX2 5PX3 5PX4 5PX5 5PX6 5PX7 5PX8 5PX9 5PXA 5PXB 5PXC 5PXD 5PXE 5PXF 5PXG 5PXH 5PXI 5PXJ 5PXK 5PXL 5PXM 5PXN 5PXO 5PXP 5PXQ 5PXR 5PXS 5PXT 5PXU 5PXV 5PXW 5PXX 5PXY 5PXZ 5PY0 5PY1 5PY2 5PY3 5PY4 5PY5 5PY6 5PY7 5PY8 5PY9 5PYA 5PYB 5PYC 5PYD 5PYE 5PYF 5PYG 5PYH 5PYI 5PYJ 5PYK 5PYL 5PYM 5PYN 5PYO 5PYP 5PYQ 5PYR 5PYS 5PYT 5PYU 5PYV 5PYW 5PYX 5PYY 5PYZ 5PZ0 5PZ1 5PZ2 5PZ3 5PZ4 5PZ5 5PZ6 5PZ7 5PZ8 5PZ9 5PZA 5PZB 5PZC 5PZD 5PZE 5PZF 5PZG 5PZH 5PZI 5PZJ 6G5N 6G5P	6WG3 6WGE 7W1M
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Nucleoplasm PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Body Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process PML Body Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Nucleus Nuclear Body SUMO Transferase Activity Chromosome, Telomeric Region Shelterin Complex Presynaptic Cytosol Postsynaptic Cytosol DNA Damage Response Nuclear Telomere Cap Complex Chromatin Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Nucleus Organization Telomere Capping Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Heterochromatin Negative Regulation Of Transcription By RNA Polymerase II Post-translational Protein Modification Chromatin Remodeling Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance RNA-templated DNA Biosynthetic Process	DNA Damage Response Generation Of Neurons PML Body Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Postsynaptic Cytosol Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Maintenance Of Protein Location In Cell PCNA Complex Replisome Negative Regulation Of DNA-templated Transcription G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Cell Communication By Chemical Coupling Maintenance Of Protein Location Maintenance Of Location In Cell Maintenance Of Location PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Telomere Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neurogenesis Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of Fas Signaling Pathway
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