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GUCY1B3 and GUCY1A2
Number of citations of the paper that reports this interaction (PMID
11572861
)
28
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
GUCY1B3
GUCY1A2
Gene Name
guanylate cyclase 1, soluble, beta 3
guanylate cyclase 1, soluble, alpha 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Guanylate Cyclase Complex, Soluble
Intracellular Membrane-bounded Organelle
Cytoplasm
Molecular Function
Guanylate Cyclase Activity
Receptor Activity
GTP Binding
Heme Binding
Metal Ion Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
Guanylate Cyclase Activity
GTP Binding
Heme Binding
Biological Process
CGMP Biosynthetic Process
Nitric Oxide Mediated Signal Transduction
Blood Coagulation
Blood Circulation
CGMP Biosynthetic Process
Signal Transduction
Blood Coagulation
Positive Regulation Of CGMP Biosynthetic Process
Intracellular Signal Transduction
Pathways
Platelet homeostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Nitric oxide stimulates guanylate cyclase
Drugs
Diseases
GWAS
Blood pressure (
21909110
)
Diastolic blood pressure (
21909115
)
Systolic blood pressure (
21909115
)
Obesity-related traits (
23251661
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Protein-Protein Interactions
4 interactors:
AGAP1
APP
GUCY1A2
HSP90AA1
8 interactors:
DLG1
DLG2
DLG3
DLG4
ERBB2IP
GUCY1B3
SNTA1
STUB1
Entrez ID
2983
2977
HPRD ID
00769
03146
Ensembl ID
ENSG00000061918
ENSG00000152402
Uniprot IDs
D6RC99
E9PCN2
Q02153
B7ZLT5
P33402
PDB IDs
2WZ1
3UVJ
Enriched GO Terms of Interacting Partners
?
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Metabolic Process
Collateral Sprouting In Absence Of Injury
Protein Import Into Mitochondrial Outer Membrane
Collateral Sprouting
Axon Midline Choice Point Recognition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Positive Regulation Of Cellular Biosynthetic Process
Neuron Remodeling
Axon Guidance
Blood Coagulation
Hemostasis
Chaperone-mediated Protein Complex Assembly
Signal Transduction
Axonogenesis
Positive Regulation Of CGMP Biosynthetic Process
Cellular Copper Ion Homeostasis
Positive Regulation Of CGMP Metabolic Process
Signaling
CGMP Biosynthetic Process
Protein Refolding
Axon Development
Regulation Of Body Fluid Levels
Cell Communication
Cell Morphogenesis Involved In Neuron Differentiation
Small Molecule Metabolic Process
Wound Healing
Chemotaxis
Regulation Of CGMP Biosynthetic Process
Copper Ion Homeostasis
Suckling Behavior
Regulation Of Catalytic Activity
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Neuron Projection Morphogenesis
Endocytosis
Nitric Oxide Metabolic Process
Positive Regulation Of Cellular Metabolic Process
CGMP Metabolic Process
Neuron Maturation
MRNA Polyadenylation
Regulation Of Cellular Response To Heat
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Response To Wounding
Reactive Nitrogen Species Metabolic Process
Regulation Of CGMP Metabolic Process
Cell Morphogenesis Involved In Differentiation
Mating Behavior
Endoplasmic Reticulum Calcium Ion Homeostasis
Cellular Response To Stimulus
Receptor Localization To Synapse
Protein Localization To Synapse
Establishment Or Maintenance Of Apical/basal Cell Polarity
Receptor Clustering
Nucleotide Phosphorylation
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Establishment Or Maintenance Of Cell Polarity
Nucleotide Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Protein Localization To Membrane
Organophosphate Metabolic Process
Synaptic Transmission
Cellular Protein Localization
Cortical Actin Cytoskeleton Organization
Cortical Cytoskeleton Organization
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Membrane Potential
Membrane Organization
Cell-cell Signaling
Protein Localization
Negative Regulation Of Phosphatase Activity
Regulation Of Sodium Ion Transport
Negative Regulation Of Dephosphorylation
Axon Guidance
Signaling
Regulation Of Ion Transmembrane Transport
Cell Communication
Regulation Of Vasoconstriction By Circulating Norepinephrine
Small Molecule Metabolic Process
Regulation Of Catalytic Activity
Cellular Localization
Regulation Of Phosphatase Activity
Axonogenesis
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Basal Protein Localization
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Dephosphorylation
Chemotaxis
Regulation Of Ion Transport
Neuron Projection Morphogenesis
Nucleobase-containing Compound Metabolic Process
Phosphate-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Protein Complex Assembly
Cell Morphogenesis Involved In Differentiation
Synapse Organization
Negative Regulation Of Peptidyl-cysteine S-nitrosylation
T Cell Cytokine Production
Tagcloud
?
2j
6j
buffer
bxd
coexpression
congruent
crosses
dba
distal
extraordinary
fluctuation
gaba
gabra1
gabra2
gabrb2
gabrb3
gabrg2
heritable
massive
naaa
neurotransmission
nos1
platforms
remarkably
subunits
unlinked
utrs
zkscan1
Tagcloud (Difference)
?
2j
6j
buffer
bxd
coexpression
congruent
crosses
dba
distal
extraordinary
fluctuation
gaba
gabra1
gabra2
gabrb2
gabrb3
gabrg2
heritable
massive
naaa
neurotransmission
nos1
platforms
remarkably
subunits
unlinked
utrs
zkscan1
Tagcloud (Intersection)
?