GUCY1B1 and AGAP1

Number of citations of the paper that reports this interaction (PubMedID 15381706)
0

Data Source:
HPRD (in vivo, two hybrid)

		GUCY1B1	AGAP1
Description		guanylate cyclase 1 soluble subunit beta 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble Protein-containing Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse	Cytoplasm Postsynaptic Endosome
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cytidylate Cyclase Activity Hsp90 Protein Binding Nitric Oxide Binding	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Intracellular Signal Transduction Nitric Oxide-cGMP-mediated Signaling Response To Oxygen Levels Cellular Response To Nitric Oxide	Protein Transport Regulation Of Modification Of Postsynaptic Structure
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		Isosorbide Vericiguat
Diseases
GWAS			Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		5 interacting genes: AGAP1 APP DSCR9 GUCY1A2 HSP90AA1	16 interacting genes: APP ARF1 ARF6 CDC42 DYRK1A GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 WEE2-AS1 ZNF534
Entrez ID		2983	116987
HPRD ID		00769	16359
Ensembl ID		ENSG00000061918	ENSG00000157985
Uniprot IDs		B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153	B2RZG9 E7EUN2 Q9UPQ3
PDB IDs		2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2 7D9R 7D9S 7D9T 7D9U 8HBE 8HBF 8HBH	7EB6
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process GTP Binding CTP Binding DATP Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Guanylate Cyclase Complex, Soluble Rho GDP-dissociation Inhibitor Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Mitochondrial Sheath Postsynaptic Endosome Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Telomerase Holoenzyme Complex Assembly Axon Choice Point Recognition	Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly
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