GUCY1B1

Description		guanylate cyclase 1 soluble subunit beta 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble Protein-containing Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cytidylate Cyclase Activity Hsp90 Protein Binding Nitric Oxide Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Intracellular Signal Transduction Nitric Oxide-cGMP-mediated Signaling Response To Oxygen Levels Cellular Response To Nitric Oxide
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		Isosorbide Vericiguat
Diseases
GWAS
Interacting Genes		5 interacting genes: AGAP1 APP DSCR9 GUCY1A2 HSP90AA1
Entrez ID		2983
HPRD ID		00769
Ensembl ID		ENSG00000061918
Uniprot IDs		B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153
PDB IDs		2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2 7D9R 7D9S 7D9T 7D9U 8HBE 8HBF 8HBH
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process GTP Binding CTP Binding DATP Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Guanylate Cyclase Complex, Soluble Rho GDP-dissociation Inhibitor Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Mitochondrial Sheath Postsynaptic Endosome Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Telomerase Holoenzyme Complex Assembly Axon Choice Point Recognition
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