AP4S1 and AFP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AP4S1	AFP
Description		adaptor related protein complex 4 subunit sigma 1	alpha fetoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Endomembrane System Membrane AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function		Protein Binding Small Molecule Binding Metal Ion Binding
	Biological Process	Protein Targeting Intracellular Protein Localization Protein Transport Vesicle-mediated Transport	Ovulation From Ovarian Follicle Apoptotic Process Immune Response Sexual Reproduction Response To Nutrient Levels Progesterone Metabolic Process Homeostasis Of Number Of Cells
Pathways		Lysosome Vesicle Biogenesis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Cerebral palsy
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494)	Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Interacting Genes		6 interacting genes: AFP APP GRB2 GTF2I HTR6 TEAD3	14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP
Entrez ID		11154	174
HPRD ID		06257	00074
Ensembl ID		ENSG00000100478	ENSG00000081051
Uniprot IDs		Q9Y587	P02771
PDB IDs			3MRK 7RE7 7RE8 7YIM 8X1N
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Guanyl-nucleotide Exchange Factor Adaptor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Grb2-EGFR Complex Asymmetric Neuroblast Division Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neurotrophin TRKA Receptor Binding Histamine Receptor Activity Axon Choice Point Recognition Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heparan Sulfate Binding Signaling Receptor Activator Activity Ovulation From Ovarian Follicle Peptidase Activator Activity	Intracellular Signal Transduction Regulation Of Protein Stability Cell Death Apoptotic Process Programmed Cell Death Endopeptidase Activity Rhythmic Process Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Cytoplasm Death Receptor Binding Negative Regulation Of Cellular Senescence Execution Phase Of Apoptosis Response To UV DNA Damage Response Regulation Of Myeloid Cell Apoptotic Process Protein Acetylation Innate Immune Response-activating Signaling Pathway Post-translational Protein Modification Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity Protein Stabilization Protein Modification Process Positive Regulation Of Protein Linear Polyubiquitination Response To Stress Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Response To Hypoxia Phospholipase A2 Activator Activity Chemokine (C-C Motif) Ligand 5 Binding P53 Binding
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