GTF2A1 and GTF2F1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		GTF2A1	GTF2F1
Description		general transcription factor IIA subunit 1	general transcription factor IIF subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Cytosol Transcription Preinitiation Complex	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIF Complex Cell Junction Protein-containing Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II General Transcription Initiation Factor Binding TFIIF-class Transcription Factor Complex Binding DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Phosphatase Activator Activity Protein Phosphatase Binding Protein Domain Specific Binding Promoter-specific Chromatin Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Response To Virus Negative Regulation Of Protein Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Neutrophil count ( 32888494) Night sleep phenotypes ( 27126917) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		26 interacting genes: BCL3 BIRC7 CREB1 CSNK2A1 CSNK2A2 GTF2A2 GTF2E1 GTF2E2 GTF2F1 HMGB1 NCOA6 NFYA PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 SP4 TAF1 TAF4 TAF4B TASP1 TBP TBPL1 TRIP4	34 interacting genes: ABL1 AHR AR ARNT ATF7IP BCL2L13 CCNT1 CDK9 CEBPA CFTR CSNK2A1 CTDP1 CTDSP1 DAPK1 FEZ1 FNDC3B FOS GTF2A1 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 JUN MAGEC1 MSX2 MYC PARP1 PSMC2 PTN SRF TAF1 TAF11 TRIM27
Entrez ID		2957	2962
HPRD ID		02748	01803
Ensembl ID		ENSG00000165417	ENSG00000125651
Uniprot IDs		P52655	P35269
PDB IDs		1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGI 7EGJ 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1F3U 1I27 1J2X 1NHA 1ONV 2K7L 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity DNA-templated Transcription Initiation Transcription Factor TFIID Complex Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation DNA-templated Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Binding RNA Metabolic Process Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding MRNA Transcription Transcription Factor TFIIA Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Factor TFIIE Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Protein Kinase CK2 Complex Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Nucleus Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Binding Male Germ Cell Nucleus Regulation Of Gene Expression	Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Initiation Nucleoplasm Host-mediated Activation Of Viral Transcription Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nucleic Acid Metabolic Process TBP-class Protein Binding Positive Regulation Of RNA Metabolic Process DNA Binding Host-mediated Perturbation Of Viral Transcription Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Activation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MiRNA Transcription Host-mediated Perturbation Of Viral Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription
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