FAM193B and PKN2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		FAM193B	PKN2
Gene Name		family with sequence similarity 193, member B	protein kinase N2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome Plasma Membrane Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Poly(A) RNA Binding RNA Polymerase Binding
	Biological Process		Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Positive Regulation Of Cytokinesis Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility
Pathways
Drugs
Diseases
GWAS			Height ( 20881960) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		10 interactors: ATXN1 CDC25A GOLGA2 GSK3A GSK3B LDOC1 MAPK8 PKN2 TRIM23 TRIM27	17 interactors: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA
Entrez ID		54540	5586
HPRD ID		07671	03972
Ensembl ID		ENSG00000146067	ENSG00000065243
Uniprot IDs		Q6IPW0	Q16513
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hypermethylation Of CpG Island Cellular Response To Interleukin-3 Negative Regulation Of Protein Binding Positive Regulation Of Mitochondrion Organization Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Mitochondrion Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Binding Positive Regulation Of Organelle Organization Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Protein Binding Regulation Of DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Response To Lithium Ion Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Regulation Of Glycogen Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Intracellular Transport Regulation Of Glycogen Metabolic Process Regulation Of Binding Regulation Of Catalytic Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Innate Immune Response Response To Metal Ion Glycogen Metabolic Process Regulation Of Immune Response Response To Light Stimulus Apoptotic Signaling Pathway Regulation Of Organelle Organization	Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Kinase Activity Cell Development Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of Endothelial Cell Migration Regulation Of T Cell Activation Cellular Response To Growth Factor Stimulus Immune System Process Regulation Of Protein Metabolic Process Response To Growth Factor Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Epithelial Cell Migration Cell Projection Organization Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Lamellipodium Organization Locomotion Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Cell Activation Positive Regulation Of T Cell Activation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cell Motility Negative Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-cell Adhesion
Tagcloud ?			abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine
Tagcloud (Difference) ?			abl amenable bioavailability bms compartmentalized compatible da dasatinib existing exquisite imatinib immobilized immunoblotting live lysates myelogenous pctk3 permeable pim pka pks problematic profiling proteome proteomic pull setups stk25 threonine
Tagcloud (Intersection) ?