FAM193B and PKN2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		FAM193B	PKN2
Description		family with sequence similarity 193 member B	protein kinase N2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Cell Projection Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding Protein Serine Kinase Activity
	Biological Process		Protein Phosphorylation Apoptotic Process Cell Adhesion Signal Transduction Epithelial Cell Migration Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Motility
Pathways			RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Height ( 25282103 31562340 20881960) Intraocular pressure ( 29617998) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 27841878 30224653) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		12 interacting genes: ATXN1 CDC25A CNOT11 GOLGA2 GSK3A GSK3B LDOC1 MAPK8 PKN2 SPANXN2 TRIM23 TRIM27	19 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA RNF10 SUMO2
Entrez ID		54540	5586
HPRD ID		07671	03972
Ensembl ID		ENSG00000146067	ENSG00000065243
Uniprot IDs		Q96PV7	Q16513
PDB IDs			4CRS 4RRV 6CCY 6GBE
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Protein Binding Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Autophagy Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Excitatory Postsynaptic Potential Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Beta-catenin Destruction Complex Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding Protein Serine Kinase Activity Tau-protein Kinase Activity Negative Regulation Of Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Protein Binding Regulation Of Glycogen Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Membrane Permeability Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Glycogen Metabolic Process Protein Modification Process Tau Protein Binding Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Postsynapse Transferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Kinase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Microtubule Anchoring At Centrosome JUN Phosphorylation Regulation Of Protein Modification Process Glycogen Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Membrane Permeability Positive Regulation Of Neuron Apoptotic Process	Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Regulation Of PERK-mediated Unfolded Protein Response ERBB Signaling Pathway Lamellipodium Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of T Cell Activation Roundabout Signaling Pathway Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Lamellipodium Organization Regulation Of Lymphocyte Activation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Stress Glutamatergic Synapse Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Population Proliferation Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Cell Cortex Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cell Activation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interleukin-18-mediated Signaling Pathway Immune System Process Vascular Endothelial Cell Response To Fluid Shear Stress Protein Kinase Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Laminar Fluid Shear Stress Cellular Response To Insulin Stimulus Ruffle Membrane Regulation Of Cell Adhesion
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