TAMALIN and GRM1

Number of citations of the paper that reports this interaction (PubMedID 11850456)
59

Data Source:
HPRD (in vivo, two hybrid)

		TAMALIN	GRM1
Description		trafficking regulator and scaffold protein tamalin	glutamate metabotropic receptor 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Nucleus Plasma Membrane Postsynaptic Density Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Cell Projection Neuron Projection Dendriole Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	PDZ Domain Binding Small GTPase Binding Identical Protein Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Regulation Of Membrane Potential Positive Regulation Of MAPK Cascade Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus L-glutamate Import Across Plasma Membrane Synaptic Signaling Via Neuropeptide Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways			G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs			Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
Diseases
GWAS			Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)
Interacting Genes		12 interacting genes: ACE2 CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 RPS6KA1 SRC	41 interacting genes: ADORA1 BECN1 CABIN1 CASR CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPRM1 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB USP7
Entrez ID		160622	2911
HPRD ID		17077	05129
Ensembl ID		ENSG00000161835	ENSG00000152822
Uniprot IDs		Q7Z6J2	Q13255 Q59HC2
PDB IDs		2PNT	3KS9 4OR2 7DGD 7DGE
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Chemical Synaptic Transmission Scaffold Protein Binding Trans-synaptic Signaling Synaptic Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Negative Regulation Of Adenylate Cyclase Activity Glutamatergic Synapse Cell-cell Signaling Neuron Projection Astrocyte Projection Signaling Cell Communication Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Group II Metabotropic Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Receptor Activity Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Dendrite Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Signal Transduction Postsynaptic Density Membrane Protein Tyrosine Kinase Activator Activity Amino Acid Transport Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Dendritic Spine	Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Surface Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Protein Phosphorylation Regulation Of Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Phosphorylation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Intracellular Signaling Cassette Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Cell Cycle Process Transferase Activity Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction ATP Binding Cell Cycle Phase Transition Regulation Of Apoptotic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Regulation Of Cell Cycle G1/S Phase Transition Nucleotide Binding Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation
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