GRASP and GRM3

Number of citations of the paper that reports this interaction (PMID 11850456)
30

Data Source:
HPRD (two hybrid)

		GRASP	GRM3
Gene Name		GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	glutamate receptor, metabotropic 3
Image
Gene Ontology Annotations	Cellular Component	Cell Junction Postsynaptic Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Presynaptic Membrane Dendritic Spine Postsynaptic Membrane Astrocyte Projection
	Molecular Function	PDZ Domain Binding ADP-ribosylation Factor Binding Identical Protein Binding	Group II Metabotropic Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity
	Biological Process	Signal Transduction Protein Localization	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases
GWAS			Brachial circumference ( 22479309)
Protein-Protein Interactions		7 interactors: CYTH3 DLG4 GABBR2 GRM1 GRM2 GRM3 GRM5	6 interactors: CALM1 GRASP GRIP1 PICK1 PPM1A SDCBP
Entrez ID		160622	2913
HPRD ID		17077	03070
Ensembl ID		ENSG00000161835	ENSG00000198822
Uniprot IDs		Q7Z6J2	A4D1D0 B7Z204 F5GYZ2 Q14832
PDB IDs		2PNT	1S8M 3SM9
Enriched GO Terms of Interacting Partners?		G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Nucleotide Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Locomotory Behavior Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Behavior Positive Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Learning G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Synaptic Plasticity Signaling Cell Communication Negative Regulation Of Catalytic Activity Cytosolic Calcium Ion Homeostasis Establishment Or Maintenance Of Cell Polarity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Negative Regulation Of Cellular Metabolic Process Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Positive Regulation Of Long-term Neuronal Synaptic Plasticity	Synaptic Transmission Cell-cell Signaling Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Transport Protein Localization Membrane Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Neuron Development Negative Regulation Of SMAD Protein Complex Assembly Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cellular Localization Response To Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Methylation Involved In Embryo Development Neuron Differentiation Cell Projection Organization N-terminal Protein Myristoylation Dendritic Spine Maintenance Protein Myristoylation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Calcium Ion Neuronal Ion Channel Clustering Substrate-dependent Cell Migration, Cell Extension Peptidyl-threonine Dephosphorylation Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Phosphoprotein Phosphatase Activity Protein Localization To Membrane Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Regulation Of Actin Nucleation Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Tagcloud ?		17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?		17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?