GRASP and GABBR2

Number of citations of the paper that reports this interaction (PMID 11850456)
30

Data Source:
HPRD (two hybrid)

		GRASP	GABBR2
Gene Name		GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	gamma-aminobutyric acid (GABA) B receptor, 2
Image
Gene Ontology Annotations	Cellular Component	Cell Junction Postsynaptic Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction G-protein Coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane
	Molecular Function	PDZ Domain Binding ADP-ribosylation Factor Binding Identical Protein Binding	G-protein Coupled GABA Receptor Activity Protein Binding
	Biological Process	Signal Transduction Protein Localization	G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		7 interactors: CYTH3 DLG4 GABBR2 GRM1 GRM2 GRM3 GRM5	9 interactors: ATF4 ATF5 GABBR1 GLP1R GRASP HTR1A KCTD12 NSF SH3GL3
Entrez ID		160622	9568
HPRD ID		17077	09552
Ensembl ID		ENSG00000161835	ENSG00000136928
Uniprot IDs		Q7Z6J2	H9NIL8 O75899
PDB IDs		2PNT	4F11 4F12
Enriched GO Terms of Interacting Partners?		G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Cell-cell Signaling Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Nucleotide Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Locomotory Behavior Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Behavior Positive Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Learning G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Synaptic Plasticity Signaling Cell Communication Negative Regulation Of Catalytic Activity Cytosolic Calcium Ion Homeostasis Establishment Or Maintenance Of Cell Polarity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Negative Regulation Of Cellular Metabolic Process Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Positive Regulation Of Long-term Neuronal Synaptic Plasticity	Gamma-aminobutyric Acid Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Golgi Vesicle Docking Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Circadian Rhythm Regulation Of Cellular Process Regulation Of Serotonin Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Olfactory Bulb Interneuron Development Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Hormone Secretion Positive Regulation Of Transcription From RNA Polymerase I Promoter Signal Transduction Olfactory Bulb Interneuron Differentiation Negative Regulation Of Astrocyte Differentiation Serotonin Receptor Signaling Pathway Serotonin Metabolic Process Rhythmic Process Regulation Of Cellular Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Receptor Recycling Regulation Of Dopamine Metabolic Process Plasma Membrane Fusion Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Tagcloud ?		17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		17q12 african americans ancestry asthma asthmatic beadchip caribbeans ethnic european explain gsdmb harbouring heritability humanexome illumina latino latinos loci maf missense missing mthfr parent representing reveals robustly trios variants	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?