BABAM1 and ABRAXAS1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		BABAM1	ABRAXAS1
Description		BRISC and BRCA1 A complex member 1	abraxas 1, BRCA1 A complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body BRCA1-A Complex BRISC Complex	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Hematopoietic Stem Cell Proliferation DNA Repair-dependent Chromatin Remodeling	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Mitotic Spindle Assembly
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Epithelial ovarian cancer ( 25581431) Mitochondrial DNA copy number ( 30704525)
Interacting Genes		7 interacting genes: ABRAXAS1 AKT1 BABAM2 BRCA1 TERF2IP TRIM27 UBC	9 interacting genes: AKT1 BABAM1 BRCA1 CFTR OGT SUMO2 UBC UIMC1 ZMYM3
Entrez ID		29086	84142
HPRD ID		13702	08584
Ensembl ID		ENSG00000105393	ENSG00000163322
Uniprot IDs		J3KQS6 Q9NWV8	Q6UWZ7
PDB IDs		6H3C 8PVY 8PY2	4JLU 4U4A 4Y18 4Y2G
Enriched GO Terms of Interacting Partners?		BRCA1-A Complex Positive Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Nuclear Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Post-translational Protein Modification Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Response To Radiation Positive Regulation Of DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Process DNA Metabolic Process Negative Regulation Of Cell Cycle Process Protein Polyubiquitination Male Germ Cell Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Cellular Response To Stress Protein Modification Process Nucleus Negative Regulation Of Cell Cycle	BRCA1-A Complex Mitotic G2 DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Ubiquitin-modified Histone Reader Activity Positive Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Protein Tag Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Response To Radiation Positive Regulation Of DNA Repair Response To Ionizing Radiation Nucleoplasm Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Repair-dependent Chromatin Remodeling Protein K6-linked Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Regulation Of Lipid Biosynthetic Process 14-3-3 Protein Binding Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nucleus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Negative Regulation Of Fatty Acid Metabolic Process Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Protein Modification By Small Protein Conjugation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Response To Alcohol Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Protein-containing Complex Ubiquitin Protein Ligase Binding Regulation Of Lipid Metabolic Process Positive Regulation Of TORC1 Signaling
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